Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

被引：95

作者：

Klonis, Nectarios

Creek, Darren J.

Tilley, Leann ^{[1
]}

机构：

[1] Univ Melbourne, Dept Biochem & Mol Biol, Mol Sci & Biotechnol Inst Bio21, Parkville, Vic 3010, Australia

来源：

CURRENT OPINION IN MICROBIOLOGY | 2013年 / 16卷 / 06期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

ANTIMALARIAL ACTIVITY; MALARIA; HEMOGLOBIN; ALKYLATION; ARTESUNATE; VACUOLE; PHARMACOKINETICS; SUSCEPTIBILITY; TOLERABILITY; DEGRADATION;

D O I：

10.1016/j.mib.2013.07.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

During the asexual blood stage of its lifecycle, the malaria parasite Plasmodium falciparum grows and multiplies in the hemoglobin-rich environment of the human erythrocyte. Although the parasite has evolved unique strategies to survive in this environment, its interaction with iron represents an Achilles' heel that is exploited by many antimalarial drugs. Recent work has shed new light on how the parasite deals with hemoglobin breakdown products and on the role of iron as a mediator of the action of the antimalarial drug, artemisinin.

引用

页码：722 / 727

页数：6

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