Suppression of immunoglobulin production in human peripheral blood mononuclear cells by monocytes via secretion of heavy-chain ferritin

被引：13
|
作者：
Yamashita, Makiko [1 ]
Harada, Gakuro [2 ]
Matsumoto, Shin-ei [1 ]
Aiba, Yoshihiro [2 ]
Ichikawa, Akira [1 ]
Fujiki, Tsukasa [1 ]
Udono, Miyako [1 ]
Kabayama, Shigeru [3 ]
Yoshida, Tadashi [4 ]
Zhang, Pingbo [1 ]
Fujii, Hiroshi [1 ]
Shirahata, Sanetaka [1 ,2 ]
Katakura, Yoshinori [1 ,2 ]
机构：
[1] Kyushu Univ, Fac Agr, Higashi Ku, Fukuoka 8128581, Japan
[2] Kyushu Univ, Grad Sch Syst Life Sci, Higashi Ku, Fukuoka 8128581, Japan
[3] Nihon Trim Co Ltd, Kita Ku, Osaka 5310076, Japan
[4] Tokyo Univ Agr & Technol, Dept Appl Biol Sci, Tokyo 1838509, Japan
来源：
IMMUNOBIOLOGY | 2014年 / 219卷 / 02期
关键词：
Ferritin; Human PBMCs; Immune suppression; Immunoglobulin production; Monocytes; LEUCINE METHYL-ESTER; ANTIBODY-PRODUCTION; DENDRITIC CELLS; LYMPHOCYTES; SUBSETS; EXPRESSION; BINDING;
D O I：
10.1016/j.imbio.2013.08.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In vitro antigen stimulation of peripheral blood mononuclear cells (PBMCs) does not induce immunoglobulin (Ig) production. However, pretreatment of PBMCs with L-leucyl-L-leucine methyl ester (LLME) prior to in vitro stimulation removes the suppression of Ig production. In the present study, we attempted to identify the target cells of LLME and determine the mechanisms by which Ig production in PBMCs is suppressed. We found that CD14(+) monocytes are involved in the suppression of Ig production in PBMCs. Furthermore, we confirmed that heavy-chain ferritin derived from CD14(+) monocytes suppresses Ig production in PBMCs, possibly through iron sequestration. (C) 2013 Elsevier GmbH. All rights reserved.
引用
收藏
页码：149 / 157
页数：9
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