Suppression of immunoglobulin production in human peripheral blood mononuclear cells by monocytes via secretion of heavy-chain ferritin

被引：13
|
作者：
Yamashita, Makiko [1 ]
Harada, Gakuro [2 ]
Matsumoto, Shin-ei [1 ]
Aiba, Yoshihiro [2 ]
Ichikawa, Akira [1 ]
Fujiki, Tsukasa [1 ]
Udono, Miyako [1 ]
Kabayama, Shigeru [3 ]
Yoshida, Tadashi [4 ]
Zhang, Pingbo [1 ]
Fujii, Hiroshi [1 ]
Shirahata, Sanetaka [1 ,2 ]
Katakura, Yoshinori [1 ,2 ]
机构：
[1] Kyushu Univ, Fac Agr, Higashi Ku, Fukuoka 8128581, Japan
[2] Kyushu Univ, Grad Sch Syst Life Sci, Higashi Ku, Fukuoka 8128581, Japan
[3] Nihon Trim Co Ltd, Kita Ku, Osaka 5310076, Japan
[4] Tokyo Univ Agr & Technol, Dept Appl Biol Sci, Tokyo 1838509, Japan
来源：
IMMUNOBIOLOGY | 2014年 / 219卷 / 02期
关键词：
Ferritin; Human PBMCs; Immune suppression; Immunoglobulin production; Monocytes; LEUCINE METHYL-ESTER; ANTIBODY-PRODUCTION; DENDRITIC CELLS; LYMPHOCYTES; SUBSETS; EXPRESSION; BINDING;
D O I：
10.1016/j.imbio.2013.08.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In vitro antigen stimulation of peripheral blood mononuclear cells (PBMCs) does not induce immunoglobulin (Ig) production. However, pretreatment of PBMCs with L-leucyl-L-leucine methyl ester (LLME) prior to in vitro stimulation removes the suppression of Ig production. In the present study, we attempted to identify the target cells of LLME and determine the mechanisms by which Ig production in PBMCs is suppressed. We found that CD14(+) monocytes are involved in the suppression of Ig production in PBMCs. Furthermore, we confirmed that heavy-chain ferritin derived from CD14(+) monocytes suppresses Ig production in PBMCs, possibly through iron sequestration. (C) 2013 Elsevier GmbH. All rights reserved.
引用
收藏
页码：149 / 157
页数：9
相关论文
共 50 条
  • [31] Secretion of plasminogen activator inhibitor 2 by human peripheral blood monocytes occurs via an endoplasmic reticulum-Golgi-independent pathway
    Ritchie, H
    Booth, NA
    EXPERIMENTAL CELL RESEARCH, 1998, 242 (02) : 439 - 450
  • [32] Growth Hormone-Releasing Hormone stimulates the secretion of interleukin 17 from human peripheral blood mononuclear cells in vitro
    Stepien, Tomasz
    Lawnicka, Hanna
    Komorowski, Jan
    Stepien, Henryk
    Siejka, Agnieszka
    NEUROENDOCRINOLOGY LETTERS, 2010, 31 (06) : 852 - 856
  • [33] Suppression by Δ9-tetrahydrocannabinol of the primary immunoglobulin M response by human peripheral blood B cells is associated with impaired STAT3 activation
    Ngaotepprutaram, Thitirat
    Kaplan, Barbara L. F.
    Carney, Stephen
    Crawford, Robert
    Kaminski, Norbert E.
    TOXICOLOGY, 2013, 310 : 84 - 91
  • [34] Allograft inflammatory factor-1 stimulates chemokine production and induces chemotaxis in human peripheral blood mononuclear cells
    Kadoya, Masatoshi
    Yamamoto, Aihiro
    Hamaguchi, Masahide
    Obayashi, Hiroshi
    Mizushima, Katsura
    Ohta, Mitsuhiro
    Seno, Takahiro
    Oda, Ryo
    Fujiwara, Hiroyoshi
    Kohno, Masataka
    Kawahito, Yutaka
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 448 (03) : 287 - 291
  • [35] IONIZING-RADIATION INCREASES TNF CACHECTIN PRODUCTION BY HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS INVITRO
    KRIVENKO, SI
    DRYK, SI
    KOMAROVSKAYA, ME
    KARKANITSA, LV
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 1992, 55 (02) : 127 - 130
  • [36] Azithromycin suppresses proliferation, interleukin production and mitogen-activated protein kinases in human peripheral-blood mononuclear cells stimulated with bacterial superantigen
    Hiwatashi, Yoko
    Maeda, Masaki
    Fukushima, Hisayo
    Onda, Kenji
    Tanaka, Sachiko
    Utsumi, Hiroya
    Hirano, Toshihiko
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2011, 63 (10) : 1320 - 1326
  • [37] Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA
    Singh, Anand
    Palanichamy, Jayanth K.
    Ramalingam, Pradeep
    Kassab, Muzaffer A.
    Bhagat, Mohita
    Andrabi, Raiees
    Luthra, Kalpana
    Sinha, Subrata
    Chattopadhyay, Parthaprasad
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 69 (02) : 404 - 415
  • [38] Mucin from rheumatoid arthritis synovial fluid enhances interleukin-6 production by human peripheral blood mononuclear cells
    Hamaguchi, Masahide
    Kawahito, Yutaka
    Ishino, Hidetaka
    Takeuchi, Noriko
    Tokunaga, Daisaku
    Hojo, Tatsuya
    Yamamoto, Aihiro
    Kadoya, Masatoshi
    Seno, Takahiro
    Kohno, Masataka
    Nakada, Hiroshi
    HUMAN IMMUNOLOGY, 2011, 72 (03) : 241 - 248
  • [39] Neferine from Nelumbo nucifera modulates oxidative stress and cytokines production during hypoxia in human peripheral blood mononuclear cells
    Baskaran, Rathinasamy
    Priya, Lohanathan Bharathi
    Kalaiselvi, Palanisamy
    Poornima, Paramasivan
    Huang, Chih-Yang
    Padma, Viswanadha Vijaya
    BIOMEDICINE & PHARMACOTHERAPY, 2017, 93 : 730 - 736
  • [40] Phagocytosis and production of H2O2 by human peripheral blood mononuclear cells from patients with obstructive jaundice
    Treglia-Dal Lago, Marisa
    Jukemura, Jose
    Cesar Machado, Marcel Cerqueira
    Monteiro da Cunha, Jose Eduardo
    Marzagao Barbuto, Jose Alexandre
    PANCREATOLOGY, 2006, 6 (04) : 273 - 278
12345