NRED: a database of long noncoding RNA expression

被引：216

作者：

Dinger, Marcel E. ^{[1
]}

Pang, Ken C. ^{[1
,2
]}

Mercer, Tim R. ^{[1
]}

Crowe, Mark L. ^{[1
]}

Grimmond, Sean M. ^{[1
]}

Mattick, John S. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, ARC Special Res Ctr Funct & Appl Genom, Brisbane, Qld 4072, Australia

[2] Austin Hosp, Melbourne Ctr Clin Sci, Ludwig Inst Canc Res, T Cell Lab, Heidelberg, Vic 3084, Australia

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

GENOME; GENE; MOUSE; TRANSCRIPTION; MICRORNAS; MAPS;

D O I：

10.1093/nar/gkn617

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mammals, thousands of long non-protein-coding RNAs (ncRNAs) (>200 nt) have recently been described. However, the biological significance and function of the vast majority of these transcripts remain unclear. We have constructed a public repository, the Noncoding RNA Expression Database (NRED), which provides gene expression information for thousands of long ncRNAs in human and mouse. The database contains both microarray and in situ hybridization data, much of which is described here for the first time. NRED also supplies a rich tapestry of ancillary information for featured ncRNAs, including evolutionary conservation, secondary structure evidence, genomic context links and antisense relationships. The database is available at http://jsm-research.imb.uq.edu.au/NRED, and the web interface enables both advanced searches and data downloads. Taken together, NRED should significantly advance the study and understanding of long ncRNAs, and provides a timely and valuable resource to the scientific community.

引用

页码：D122 / D126

页数：5

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