AltitudeOmics: The Integrative Physiology of Human Acclimatization to Hypobaric Hypoxia and Its Retention upon Reascent

被引：82

作者：

Subudhi, Andrew W. ^{[1
,2
]}

Bourdillon, Nicolas ^{[3
,4
]}

Bucher, Jenna ^{[5
]}

Davis, Christopher ^{[1
]}

Elliott, Jonathan E. ^{[5
]}

Eutermoster, Morgan ^{[1
]}

Evero, Oghenero ^{[1
]}

Fan, Jui-Lin ^{[3
,4
,6
]}

Jameson-Van Houten, Sonja ^{[1
]}

Julian, Colleen G. ^{[1
]}

Kark, Jonathan ^{[1
]}

Kark, Sherri ^{[1
]}

Kayser, Bengt ^{[3
]}

Kern, Julia P. ^{[5
]}

Kim, See Eun ^{[5
]}

Lathan, Corinna ^{[7
]}

Laurie, Steven S. ^{[5
]}

Lovering, Andrew T. ^{[5
]}

Paterson, Ryan ^{[1
]}

Polaner, David M. ^{[8
,9
,10
]}

Ryan, Benjamin J. ^{[11
]}

Spira, James L. ^{[12
,13
]}

Tsao, Jack W. ^{[14
]}

Wachsmuth, Nadine B. ^{[15
]}

Roach, Robert C. ^{[1
]}

机构：

[1] Univ Colorado, Altitude Res Ctr, Dept Emergency Med, Aurora, CO 80045 USA

[2] Univ Colorado, Dept Biol, Colorado Springs, CO 80907 USA

[3] Univ Lausanne, Fac Biol & Med, Inst Sports Sci, Lausanne, Switzerland

[4] Univ Lausanne, Fac Biol & Med, Dept Physiol, Lausanne, Switzerland

[5] Univ Oregon, Dept Human Physiol, Eugene, OR 97403 USA

[6] Univ Lausanne, Leman Doctoral Sch Neurosci, Lausanne, Switzerland

[7] AnthroTronix Inc, Silver Spring, MD USA

[8] Univ Colorado, Sch Med, Dept Anesthesiol, Aurora, CO USA

[9] Univ Colorado, Sch Med, Dept Pediat, Aurora, CO USA

[10] Childrens Hosp Colorado, Aurora, CO USA

[11] Univ Colorado, Dept Integrat Physiol, Boulder, CO USA

[12] Univ Hawaii, US Dept Vet Affairs, Pacific Islands Hlth Care Syst, Natl Ctr PTSD, Honolulu, HI 96822 USA

[13] Univ Hawaii, John A Burns Sch Med, Dept Psychiat, Honolulu, HI 96822 USA

[14] US Navy Bur Med & Surg, Wounded Ill & Injured Directorate M9, Falls Church, VA USA

[15] Univ Bayreuth, Dept Sports Med Sports Physiol, Bayreuth, Germany

来源：

PLOS ONE | 2014年 / 9卷 / 03期

基金：

美国国家卫生研究院;

关键词：

OPERATION EVEREST-II; PULMONARY GAS-EXCHANGE; ACUTE MOUNTAIN-SICKNESS; PLASMA-VOLUME EXPANSION; COGNITIVE PERFORMANCE; SIMULATED ASCENT; OXYGEN-TRANSPORT; EXERCISE; VO(2MAX); NEOCYTOLYSIS;

D O I：

10.1371/journal.pone.0092191

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An understanding of human responses to hypoxia is important for the health of millions of people worldwide who visit, live, or work in the hypoxic environment encountered at high altitudes. In spite of dozens of studies over the last 100 years, the basic mechanisms controlling acclimatization to hypoxia remain largely unknown. The AltitudeOmics project aimed to bridge this gap. Our goals were 1) to describe a phenotype for successful acclimatization and assess its retention and 2) use these findings as a foundation for companion mechanistic studies. Our approach was to characterize acclimatization by measuring changes in arterial oxygenation and hemoglobin concentration [Hb], acute mountain sickness (AMS), cognitive function, and exercise performance in 21 subjects as they acclimatized to 5260 m over 16 days. We then focused on the retention of acclimatization by having subjects reascend to 5260 m after either 7 (n = 14) or 21 (n = 7) days at 1525 m. At 16 days at 5260 m we observed: 1) increases in arterial oxygenation and [Hb] (compared to acute hypoxia: PaO2 rose 964 mmHg to 45 +/- 4 while PaCO2 dropped a further 6 +/- 3 mmHg to 21 +/- 3, and [Hb] rose 1.8 +/- 0.7 g/dL to 16 +/- 2 g/dL; 2) no AMS; 3) improved cognitive function; and 4) improved exercise performance by 8 +/- 8% (all changes p<0.01). Upon reascent, we observed retention of arterial oxygenation but not [Hb], protection from AMS, retention of exercise performance, less retention of cognitive function; and noted that some of these effects lasted for 21 days. Taken together, these findings reveal new information about retention of acclimatization, and can be used as a physiological foundation to explore the molecular mechanisms of acclimatization and its retention.

引用

页数：11

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[1] Neocytolysis: Physiological down-regulator of red-cell mass [J].