miRNA therapeutics in cardiovascular diseases: promises and problems

被引：77

作者：

Nouraee, Nazila ^{[1
]}

Mowla, Seyed J. ^{[1
]}

机构：

[1] Tarbiat Modares Univ, Fac Biol Sci, Dept Mol Genet, Tehran, Iran

来源：

FRONTIERS IN GENETICS | 2015年 / 6卷

关键词：

ACUTE MYOCARDIAL-INFARCTION; CIRCULATING MICRORNAS; ATRIAL-FIBRILLATION; CARDIAC FIBROSIS; HEART-FAILURE; EXOSOMES; BIOMARKER; BIOGENESIS; DIAGNOSIS; CANCER;

D O I：

10.3389/fgene.2015.00232

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

microRNAs (miRNAs) are a novel class of non-coding RNAs which found their way into the clinic due to their fundamental roles in cellular processes such as differentiation, proliferation, and apoptosis. Recently, miRNAs have been known as micromodulators in cellular communications being involved in cell signaling and microenvironment remodeling. In this review, we will focus on the role of miRNAs in cardiovascular diseases (CVDs) and their reliability as diagnostic and therapeutic biomarkers in these conditions. CVDs comprise a variety of blood vessels and heart disorders with a high rate of morbidity and mortality worldwide. This necessitates introduction of novel molecular biomarkers for early detection, prevention, or treatment of these diseases. miRNAs, due to their stability, tissue-specific expression pattern and secretion to the corresponding body fluids, are attractive targets for cardiovascular-associated therapeutics. Explaining the challenges ahead of miRNA-based therapies, we will discuss the exosomes as delivery packages for miRNA drugs and promising novel strategies for the future of miRNA-based therapeutics. These approaches provide insights to the future of personalized medicine for the treatment of CVDs.

引用

页数：6

共 60 条

[11] Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease [J].

Corsten, Maarten F. ;

Dennert, Robert ;

Jochems, Sylvia ;

Kuznetsova, Tatiana ;

Devaux, Yvan ;

Hofstra, Leon ;

Wagner, Daniel R. ;

Staessen, Jan A. ;

Heymans, Stephane ;

Schroen, Blanche .

CIRCULATION-CARDIOVASCULAR GENETICS, 2010, 3 (06) :499-506

[12] Diagnostic and prognostic value of circulating microRNAs in patients with acute chest pain [J].

Devaux, Y. ;

Mueller, M. ;

Haaf, P. ;

Goretti, E. ;

Twerenbold, R. ;

Zangrando, J. ;

Vausort, M. ;

Reichlin, T. ;

Wildi, K. ;

Moehring, B. ;

Wagner, D. R. ;

Mueller, C. .

JOURNAL OF INTERNAL MEDICINE, 2015, 277 (02) :260-271

[13] A Panel of 4 microRNAs Facilitates the Prediction of Left Ventricular Contractility after Acute Myocardial Infarction [J].

Devaux, Yvan ;

Vausort, Melanie ;

McCann, Gerry P. ;

Kelly, Dominic ;

Collignon, Olivier ;

Ng, Leong L. ;

Wagner, Daniel R. ;

Squire, Iain B. .

PLOS ONE, 2013, 8 (08)

[14] miR-133 and miR-30 Regulate Connective Tissue Growth Factor Implications for a Role of MicroRNAs in Myocardial Matrix Remodeling [J].

Duisters, Rudy F. ;

Tijsen, Anke J. ;

Schroen, Blanche ;

Leenders, Joost J. ;

Lentink, Viola ;

van der Made, Ingeborg ;

Herias, Veronica ;

van Leeuwen, Rick E. ;

Schellings, Mark W. ;

Barenbrug, Paul ;

Maessen, Jos G. ;

Heymans, Stephane ;

Pinto, Yigal M. ;

Creemers, Esther E. .

CIRCULATION RESEARCH, 2009, 104 (02) :170-U61

[15] miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts [J].

Eiring, Anna M. ;

Harb, Jason G. ;

Neviani, Paolo ;

Garton, Christopher ;

Oaks, Joshua J. ;

Spizzo, Riccardo ;

Liu, Shujun ;

Schwind, Sebastian ;

Santhanam, Ramasamy ;

Hickey, Christopher J. ;

Becker, Heiko ;

Chandler, Jason C. ;

Andino, Raul ;

Cortes, Jorge ;

Hokland, Peter ;

Huettner, Claudia S. ;

Bhatia, Ravi ;

Roy, Denis C. ;

Liebhaber, Stephen A. ;

Caligiuri, Michael A. ;

Marcucci, Guido ;

Garzon, Ramiro ;

Croce, Carlo M. ;

Calin, George A. ;

Perrotti, Danilo .

CELL, 2010, 140 (05) :652-665

[16] MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response [J].

Fabbri, Muller ;

Paone, Alessio ;

Calore, Federica ;

Galli, Roberta ;

Gaudio, Eugenio ;

Santhanam, Ramasamy ;

Lovat, Francesca ;

Fadda, Paolo ;

Mao, Charlene ;

Nuovo, Gerard J. ;

Zanesi, Nicola ;

Crawford, Melissa ;

Ozer, Gulcin H. ;

Wernicke, Dorothee ;

Alder, Hansjuerg ;

Caligiuri, Michael A. ;

Nana-Sinkam, Patrick ;

Perrotti, Danilo ;

Croce, Carlo M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (31) :E2110-E2116

[17] Circulating MicroRNAs in Patients With Coronary Artery Disease [J].

Fichtlscherer, Stephan ;

De Rosa, Salvatore ;

Fox, Henrik ;

Schwietz, Thomas ;

Fischer, Ariane ;

Liebetrau, Christoph ;

Weber, Michael ;

Hamm, Christian W. ;

Roexe, Tino ;

Mueller-Ardogan, Marga ;

Bonauer, Angelika ;

Zeiher, Andreas M. ;

Dimmeler, Stefanie .

CIRCULATION RESEARCH, 2010, 107 (05) :677-U257

[18] MicroRNA-24 Regulates Vascularity After Myocardial Infarction [J].

Fiedler, Jan ;

Jazbutyte, Virginija ;

Kirchmaier, Bettina C. ;

Gupta, Shashi K. ;

Lorenzen, Johan ;

Hartmann, Dorothee ;

Galuppo, Paolo ;

Kneitz, Susanne ;

Pena, John T. G. ;

Sohn-Lee, Cherin ;

Loyer, Xavier ;

Soutschek, Juergen ;

Brand, Thomas ;

Tuschl, Thomas ;

Heineke, Joerg ;

Martin, Ulrich ;

Schulte-Merker, Stefan ;

Ertl, Georg ;

Engelhardt, Stefan ;

Bauersachs, Johann ;

Thum, Thomas .

CIRCULATION, 2011, 124 (06) :720-U178

[19] Assessment of Plasma miRNAs in Congestive Heart Failure [J].

Fukushima, Yasue ;

Nakanishi, Michio ;

Nonogi, Hiroshi ;

Goto, Yoichi ;

Iwai, Naoharu .

CIRCULATION JOURNAL, 2011, 75 (02) :336-340

[20] Identification of Therapeutic Covariant MicroRNA Clusters in Hypoxia-Treated Cardiac Progenitor Cell Exosomes Using Systems Biology [J].

Gray, Warren D. ;

French, Kristin M. ;

Ghosh-Choudhary, Shohini ;

Maxwell, Joshua T. ;

Brown, Milton E. ;

Platt, Manu O. ;

Searles, Charles D. ;

Davis, Michael E. .

CIRCULATION RESEARCH, 2015, 116 (02) :255-U119

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