Mesenchymal stem cells derived from vertebrae (vMSCs) show best biological properties

被引：16

作者：

Brodano, Giovanni Barbanti ^{[1
]}

Terzi, Silvia ^{[1
]}

Trombi, Luisa ^{[2
]}

Griffoni, Cristiana ^{[1
]}

Valtieri, Mauro ^{[3
]}

Boriani, Stefano ^{[1
]}

Magli, Maria Cristina ^{[4
]}

机构：

[1] Rizzoli Orthoped Inst, Dept Oncol & Degenerat Spine Surg, I-40136 Bologna, Italy

[2] Univ Pisa, Dept Oncol Transplants & New Adv Med, Div Hematol, Pisa, Italy

[3] Ist Super Sanita, Dept Hematol Oncol & Mol Med, I-00161 Rome, Italy

[4] CNR, Inst Biomed Technol, I-56100 Pisa, Italy

来源：

EUROPEAN SPINE JOURNAL | 2013年 / 22卷

关键词：

Mesenchymal stem cells; Vertebraderived bone marrow; In vitro growth; Differentiation; Spine fusion; BONE-GRAFT SUBSTITUTES; MUSCULOSKELETAL REGENERATION; SPINAL-FUSION; RAT MODEL; THERAPY; HOX;

D O I：

10.1007/s00586-013-3028-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Due to their properties and characteristics human mesenchymal stem cells (MSCs) appear to have great therapeutic potential. Many different populations of MSCs have been described and to understand whether they have equivalent biological properties is a critical issue for their therapeutic application. We proposed to analyze the in vitro growth kinetics of MSCs derived from different body sites (iliac crest bone marrow, vertebrae bone marrow, colon mucosa, dental pulp). Mesenchymal stem cells derived from vertebrae can be maintained in culture for a greater number of steps and they also generate mature cells of all mesenchymal lineages with greater efficiency, when induced into osteogenic, adipogenic and chondrogenic differentiation. The ability of vertebrae-derived MSCs in terms of expansion and differentiation is very interesting at the light of a clinical application for bone fusion in spine surgery.

引用

页码：S979 / S984

页数：6

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