Nutrient Sensing, Metabolism, and Cell Growth Control

被引：272

作者：

Yuan, Hai-Xin ^{[1
,2
]}

Xiong, Yue ^{[3
]}

Guan, Kun-Liang ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

[3] Univ N Carolina, Dept Biochem & Biophys, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

MOLECULAR CELL | 2013年 / 49卷 / 03期

关键词：

ACTIVATED PROTEIN-KINASE; TRANSFER-RNA SYNTHETASE; ACETYL-COA CARBOXYLASE; INDUCIBLE FACTOR HIF; DIET-INDUCED OBESITY; MTOR COMPLEX 1; SKELETAL-MUSCLE; MAMMALIAN TARGET; RAG GTPASES; AMINO-ACIDS;

D O I：

10.1016/j.molcel.2013.01.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell growth is regulated by coordination of both extracellular nutrients and intracellular metabolite concentrations. AMP-activated kinase and mammalian target of rapamycin complex 1 serve as key molecules that sense cellular energy and nutrients levels, respectively. In addition, the members of the dioxygenase family, including prolylhydroxylase, lysine demethylase, and DNA demethylase, have emerged as possible sensors of intracellular metabolic status. The interplay among nutrients, metabolites, gene expression, and protein modification are involved in the coordination of cell growth with extracellular and intracellular conditions.

引用

页码：379 / 387

页数：9

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