Overexpression of IL-15 in vivo increases antigen-driven memory CD8+ T cells following a microbe exposure

被引:93
作者
Yajima, T
Nishimura, H
Ishimitsu, R
Watase, T
Busch, DH
Pamer, EG
Kuwano, H
Yoshikai, Y [1 ]
机构
[1] Nagoya Univ, Sch Med, Res Inst Dis Mech & Control, Lab Host Def, Nagoya, Aichi 4668550, Japan
[2] Gunma Univ, Sch Med, Dept Surg 1, Maebashi, Gumma, Japan
[3] Yale Univ, Sch Med, Infect Dis Sect, New Haven, CT 06520 USA
[4] Yale Univ, Sch Med, Immunol Sect, New Haven, CT 06520 USA
[5] Mem Sloan Kettering Canc Ctr, Program Immunol, Sloan Kettering Inst, Dept Med,Infect Dis Serv, New York, NY 10021 USA
关键词
D O I
10.4049/jimmunol.168.3.1198
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To elucidate potential roles of IL-15 in the maintenance of memory CD8(+) T cells, we followed the fate of Ag-specific CD8(+) T cells directly visualized with MHC class I tetramers coupled with listeriolysin O (LLO)(91-99) in IL-15 transgenic (Tg) mice after Listeria monocytogenes infection. The numbers of LLO91-99-positive memory CD8(+) T cells were significantly higher at 3 and 6 wk after infection than those in non-Tg mice. The LLO91-99-positive CD8(+) T cells produced IFN-gamma in response to LLO91-99, and an adoptive transfer of CD8(+) T cells from IL-15 Tg mice infected with L monocytogenes conferred a higher level of resistance against L. monocytogenes in normal mice. The CD44(+)CD8(+) T cells from infected IL-15 Tg mice expressed the higher level of Bcl-2. Transferred CD44(+)CD8(+) T cells divided more vigorously in naive IL-15 Tg mice than in non-Tg mice. These results suggest that IL-15 plays an important role in long-term maintenance of Ag-specific memory CD8(+) T cells following microbial exposure via promotion of cell survival and homeostatic proliferation.
引用
收藏
页码:1198 / 1203
页数:6
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