Quantification of ion-induced molecular fragmentation of isolated 2-deoxy-D-ribose molecules

被引：64

作者：

Alvarado, F ^{[1
]}

Bari, S ^{[1
]}

Hoekstra, R ^{[1
]}

Schlathölter, T ^{[1
]}

机构：

[1] Univ Groningen, KVI Atom Phys, NL-9747 AA Groningen, Netherlands

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2006年 / 8卷 / 16期

关键词：

D O I：

10.1039/b517109a

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Recent experiments on low energy ion-induced damage to DNA building blocks indicate that ion induced DNA damage is dominated by deoxyribose disintegration (Phys. Rev. Lett., 2005, 95, 153201). We have studied interactions of keV H+ and Heq+ with isolated deoxyribose molecules by means of high resolution time-of-flight spectrometry. Extensive statistical fragmentation of the molecules is observed. The fragment distribution is found to follow a power law dependence. The exponent can be used to characterize and quantify the molecular damage.

引用

页码：1922 / 1928

页数：7

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