Quantification of ion-induced molecular fragmentation of isolated 2-deoxy-D-ribose molecules

被引：64

作者：

Alvarado, F ^{[1
]}

Bari, S ^{[1
]}

Hoekstra, R ^{[1
]}

Schlathölter, T ^{[1
]}

机构：

[1] Univ Groningen, KVI Atom Phys, NL-9747 AA Groningen, Netherlands

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2006年 / 8卷 / 16期

关键词：

D O I：

10.1039/b517109a

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Recent experiments on low energy ion-induced damage to DNA building blocks indicate that ion induced DNA damage is dominated by deoxyribose disintegration (Phys. Rev. Lett., 2005, 95, 153201). We have studied interactions of keV H+ and Heq+ with isolated deoxyribose molecules by means of high resolution time-of-flight spectrometry. Extensive statistical fragmentation of the molecules is observed. The fragment distribution is found to follow a power law dependence. The exponent can be used to characterize and quantify the molecular damage.

引用

页码：1922 / 1928

页数：7

共 33 条

[1] Dissociation of water molecules upon keV H+- and Heq+-induced ionization [J].

Alvarado, F ;

Hoekstra, R ;

Schlathölter, T .

JOURNAL OF PHYSICS B-ATOMIC MOLECULAR AND OPTICAL PHYSICS, 2005, 38 (22) :4085-4094

[2] Universality in fragmentation [J].

Åström, JA ;

Holian, BL ;

Timonen, J .

PHYSICAL REVIEW LETTERS, 2000, 84 (14) :3061-3064

[3] Theoretical treatment of charge-transfer processes induced by collision of Cq+ ions with uracil -: art. no. 052706 [J].

Bacchus-Montabonel, MC ;

Labuda, M ;

Tergiman, YS ;

Sienkiewicz, JE .

PHYSICAL REVIEW A, 2005, 72 (05)

[4]

BARI S, 2006, IN PRESS

[5] Charge driven fragmentation of nucleobases -: art. no. 053401 [J].

de Vries, J ;

Hoekstra, R ;

Morgenstern, R ;

Schlathölter, T .

PHYSICAL REVIEW LETTERS, 2003, 91 (05)

[6] Multiple ionization and fragmentation of the DNA base thymine by interaction with Cq+ ions [J].

de Vries, J ;

Hoekstra, R ;

Morgenstern, R ;

Schlathölter, T .

EUROPEAN PHYSICAL JOURNAL D, 2003, 24 (1-3) :161-164

[7] Cq+-induced excitation and fragmentation of uracil:: effects of the projectile electronic structure [J].

de Vries, J ;

Hoekstra, R ;

Morgenstern, R ;

Schlathölter, T .

JOURNAL OF PHYSICS B-ATOMIC MOLECULAR AND OPTICAL PHYSICS, 2002, 35 (21) :4373-4381

[8] Fragmentation dynamics of condensed phase thymine by low-energy (10-200 eV) heavy-ion impact [J].

Deng, ZW ;

Imhoff, M ;

Huels, MA .

JOURNAL OF CHEMICAL PHYSICS, 2005, 123 (14)

[9] Beyond the Bragg peak: Hyperthermal heavy ion damage to DNA components [J].

Deng, ZW ;

Bald, I ;

Illenberger, E ;

Huels, MA .

PHYSICAL REVIEW LETTERS, 2005, 95 (15)

[10] COLLISIONAL MODEL OF ASTEROIDS AND THEIR DEBRIS [J].

DOHNANYI, JS .

JOURNAL OF GEOPHYSICAL RESEARCH, 1969, 74 (10) :2531-&

← 1 2 3 4 →