Crohn disease;
ulcerative colitis;
children and adolescents;
complementary therapies;
communication;
QUALITY-OF-LIFE;
PEDIATRIC-PATIENTS;
CROHNS-DISEASE;
ADOLESCENTS;
THERAPIES;
POPULATION;
ATTITUDES;
PATTERNS;
COLITIS;
ARTICLE;
D O I:
10.3389/fped.2013.00009
中图分类号:
R72 [儿科学];
学科分类号:
100202 ;
摘要:
The Inflammatory Bowel Diseases (IBDs) are diagnosed more commonly in children and adolescents. Following diagnosis, the key objectives are to achieve and then maintain remission. Although some therapies are able to effectively modify and modulate inflammatory events, none of the available interventions cure these conditions. Consequently, children and their parents face uncertainty and may look to alternative management options as ways to help their child, which may include various complementary and alternative medicines (CAMs). A number of studies have shown that many children with IBD receive or are given CAM agents. This article reviews the rates and patterns of CAM use in children with IBD, and emphasizes the increasing importance of these aspects of the management of children with IBD.
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Royal Hosp Sick Children, Dept Paediat Gastroenterol & Nutr, Edinburgh EH9 1LF, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Van Limbergent, Johan
;
Russell, Richard K.
论文数: 0引用数: 0
h-index: 0
机构:
Yorkhill Hosp, Dept Paediat Gastroenterol, Glasgow, Lanark, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Russell, Richard K.
;
Drummond, Hazel E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Drummond, Hazel E.
;
Aldhous, Marian C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Aldhous, Marian C.
;
Round, Nicola K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Royal Hosp Sick Children, Dept Paediat Gastroenterol & Nutr, Edinburgh EH9 1LF, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Round, Nicola K.
;
Nimmo, Elaine R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Nimmo, Elaine R.
;
Smith, Linda
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Smith, Linda
;
Gillett, Peter M.
论文数: 0引用数: 0
h-index: 0
机构:
Royal Hosp Sick Children, Dept Paediat Gastroenterol & Nutr, Edinburgh EH9 1LF, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Gillett, Peter M.
;
McGrogan, Paraic
论文数: 0引用数: 0
h-index: 0
机构:
Yorkhill Hosp, Dept Paediat Gastroenterol, Glasgow, Lanark, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
McGrogan, Paraic
;
Weaver, Lawrence T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Glasgow, Dept Child Hlth, Glasgow, Lanark, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Weaver, Lawrence T.
;
Bisset, W. Michael
论文数: 0引用数: 0
h-index: 0
机构:
Royal Aberdeen Childrens Hosp, Dept Paediat Gastroenterol, Aberdeen, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Bisset, W. Michael
;
Mahdi, Gamal
论文数: 0引用数: 0
h-index: 0
机构:
Royal Aberdeen Childrens Hosp, Dept Paediat Gastroenterol, Aberdeen, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Mahdi, Gamal
;
Arnott, Ian D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Arnott, Ian D.
;
Satsangi, Jack
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Satsangi, Jack
;
Wilsont, David C.
论文数: 0引用数: 0
h-index: 0
机构:
Royal Hosp Sick Children, Dept Paediat Gastroenterol & Nutr, Edinburgh EH9 1LF, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
机构:
Ctr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Vernier-Massouille, Gwenola
;
Balde, Mamadou
论文数: 0引用数: 0
h-index: 0
机构:
Hop Calmette, Serv Epidemiol & Sante Publ, EPIMAD, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Balde, Mamadou
;
Salleron, Julia
论文数: 0引用数: 0
h-index: 0
机构:
Fac Med, Biostat Unit, CERIM, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Salleron, Julia
;
Turck, Dominique
论文数: 0引用数: 0
h-index: 0
机构:
Hop Jeanne Flandre, Pediat Clin, EPIMAD, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Turck, Dominique
;
Dupas, Jean Louis
论文数: 0引用数: 0
h-index: 0
机构:
Hop Nord Amiens, Ctr Amiens, EPIMAD, Amiens, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Dupas, Jean Louis
;
Mouterde, Olivier
论文数: 0引用数: 0
h-index: 0
机构:
Rouen Univ Hosp, Ctr Rouen, EPIMAD, Rouen, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Mouterde, Olivier
;
Merle, Veronique
论文数: 0引用数: 0
h-index: 0
机构:
Rouen Univ Hosp, Ctr Rouen, EPIMAD, Rouen, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Merle, Veronique
;
Salomez, Jean Louis
论文数: 0引用数: 0
h-index: 0
机构:
Hop Calmette, Serv Epidemiol & Sante Publ, EPIMAD, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Salomez, Jean Louis
;
Branche, Julien
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Branche, Julien
;
Marti, Raymond
论文数: 0引用数: 0
h-index: 0
机构:
Hop Calmette, Serv Epidemiol & Sante Publ, EPIMAD, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Marti, Raymond
;
Lerebours, Eric
论文数: 0引用数: 0
h-index: 0
机构:
Rouen Univ Hosp, Ctr Rouen, EPIMAD, Rouen, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Lerebours, Eric
;
论文数: 引用数:
h-index:
机构:
Cortot, Antoine
;
Gower-Rousseau, Corinne
论文数: 0引用数: 0
h-index: 0
机构:
Hop Calmette, Serv Epidemiol & Sante Publ, EPIMAD, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Gower-Rousseau, Corinne
;
Colombel, Jean Frederic
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Royal Hosp Sick Children, Dept Paediat Gastroenterol & Nutr, Edinburgh EH9 1LF, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Van Limbergent, Johan
;
Russell, Richard K.
论文数: 0引用数: 0
h-index: 0
机构:
Yorkhill Hosp, Dept Paediat Gastroenterol, Glasgow, Lanark, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Russell, Richard K.
;
Drummond, Hazel E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Drummond, Hazel E.
;
Aldhous, Marian C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Aldhous, Marian C.
;
Round, Nicola K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Royal Hosp Sick Children, Dept Paediat Gastroenterol & Nutr, Edinburgh EH9 1LF, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Round, Nicola K.
;
Nimmo, Elaine R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Nimmo, Elaine R.
;
Smith, Linda
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Smith, Linda
;
Gillett, Peter M.
论文数: 0引用数: 0
h-index: 0
机构:
Royal Hosp Sick Children, Dept Paediat Gastroenterol & Nutr, Edinburgh EH9 1LF, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Gillett, Peter M.
;
McGrogan, Paraic
论文数: 0引用数: 0
h-index: 0
机构:
Yorkhill Hosp, Dept Paediat Gastroenterol, Glasgow, Lanark, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
McGrogan, Paraic
;
Weaver, Lawrence T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Glasgow, Dept Child Hlth, Glasgow, Lanark, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Weaver, Lawrence T.
;
Bisset, W. Michael
论文数: 0引用数: 0
h-index: 0
机构:
Royal Aberdeen Childrens Hosp, Dept Paediat Gastroenterol, Aberdeen, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Bisset, W. Michael
;
Mahdi, Gamal
论文数: 0引用数: 0
h-index: 0
机构:
Royal Aberdeen Childrens Hosp, Dept Paediat Gastroenterol, Aberdeen, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Mahdi, Gamal
;
Arnott, Ian D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Arnott, Ian D.
;
Satsangi, Jack
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Satsangi, Jack
;
Wilsont, David C.
论文数: 0引用数: 0
h-index: 0
机构:
Royal Hosp Sick Children, Dept Paediat Gastroenterol & Nutr, Edinburgh EH9 1LF, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland
机构:
Ctr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Vernier-Massouille, Gwenola
;
Balde, Mamadou
论文数: 0引用数: 0
h-index: 0
机构:
Hop Calmette, Serv Epidemiol & Sante Publ, EPIMAD, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Balde, Mamadou
;
Salleron, Julia
论文数: 0引用数: 0
h-index: 0
机构:
Fac Med, Biostat Unit, CERIM, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Salleron, Julia
;
Turck, Dominique
论文数: 0引用数: 0
h-index: 0
机构:
Hop Jeanne Flandre, Pediat Clin, EPIMAD, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Turck, Dominique
;
Dupas, Jean Louis
论文数: 0引用数: 0
h-index: 0
机构:
Hop Nord Amiens, Ctr Amiens, EPIMAD, Amiens, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Dupas, Jean Louis
;
Mouterde, Olivier
论文数: 0引用数: 0
h-index: 0
机构:
Rouen Univ Hosp, Ctr Rouen, EPIMAD, Rouen, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Mouterde, Olivier
;
Merle, Veronique
论文数: 0引用数: 0
h-index: 0
机构:
Rouen Univ Hosp, Ctr Rouen, EPIMAD, Rouen, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Merle, Veronique
;
Salomez, Jean Louis
论文数: 0引用数: 0
h-index: 0
机构:
Hop Calmette, Serv Epidemiol & Sante Publ, EPIMAD, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Salomez, Jean Louis
;
Branche, Julien
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Branche, Julien
;
Marti, Raymond
论文数: 0引用数: 0
h-index: 0
机构:
Hop Calmette, Serv Epidemiol & Sante Publ, EPIMAD, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Marti, Raymond
;
Lerebours, Eric
论文数: 0引用数: 0
h-index: 0
机构:
Rouen Univ Hosp, Ctr Rouen, EPIMAD, Rouen, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Lerebours, Eric
;
论文数: 引用数:
h-index:
机构:
Cortot, Antoine
;
Gower-Rousseau, Corinne
论文数: 0引用数: 0
h-index: 0
机构:
Hop Calmette, Serv Epidemiol & Sante Publ, EPIMAD, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France
Gower-Rousseau, Corinne
;
Colombel, Jean Frederic
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, FranceCtr Hosp Reg & Univ Lille, Hop Claude Huriez, Dept Hepatogastroenterol, Serv Hepatogastroenterol,Registre Malad Inflammat, F-59037 Lille, France