Aortic arch tortuosity, a novel biomarker for thoracic aortic disease, is increased in adults with bicuspid aortic valve

被引:31
|
作者
Alhafez, Bader Aldeen [1 ]
Van Thi Thanh Truong [2 ]
Ocazionez, Daniel [3 ]
Sohrabi, Sahand [1 ]
Sandhu, Harleen [4 ]
Estrera, Anthony [4 ]
Safi, Hazim J. [4 ]
Evangelista, Artur [5 ]
Hurtado, Lydia Dux-Santoy [5 ]
Guala, Andrea [5 ]
Prakash, Siddharth K. [1 ]
机构
[1] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Internal Med, 6431 Fannin St,MSB 1-150, Houston, TX 77030 USA
[2] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Ctr Clin Res & Evidence Based Med, 6431 Fannin St,MSB 2-106, Houston, TX 77030 USA
[3] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Diagnost & Intervent Imaging, 6431 Fannin St,2-130B, Houston, TX 77030 USA
[4] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Cardiothorac & Vasc Surg, 6431 Fannin St,Suite 2850, Houston, TX 77030 USA
[5] Vall Hebron Univ Hosp, CIBER CV, Dept Cardiol, Passeig Vall Hebron 119-129, Barcelona 08035, Spain
关键词
Bicuspid aortic valve; Tortuosity; Thoracic aortic aneurysm; Thoracic aortic dissection; WALL SHEAR-STRESS; MAGNETIC-RESONANCE; VERTEBRAL ARTERY; ASCENDING AORTA; TURNER-SYNDROME; KNOWLEDGE GAPS; FLOW PATTERNS; ASSOCIATION; REPLACEMENT; PHENOTYPE;
D O I
10.1016/j.ijcard.2018.10.052
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Arterial tortuosity has emerged as a predictor of adverse outcomes in congenital aortopathies using 3D reconstructed images. We validated a new method to estimate aortic arch tortuosity on 2D CT. We hypothesize that arch tortuosity may identify bicuspid aortic valve (BAV) patients at high risk to develop thoracic aortic aneurysms or aortic dissections (TAD). Methods: BAV subjects with chest CT scans were retrospectively identified in our clinical records and matched to tricuspid aortic valve (TAV) controls by age, gender, and presentation with TAD. Subjects with prior ascending aortic intervention were excluded. Measurements included aortic arch tortuosity, length, angle, width and height. Total aortic tortuosity was estimated in subjects with available abdominal images. Results: 120 BAV and 234 TAV subjects were included. Our 2D measurements were highly correlated with 3D midline arch measurements and had high inter-and intra-observer reliability. Compared to TAV, BAV subjects had increased arch tortuosity (median 1.76 [Q1-Q3: 1.62-1.95] vs. 1.63 [1.53-1.78], P < 0.01), length (149 [136-160] vs. 135 [122-152] mm, P < 0.01), height (46 [41-53] vs. 39 [34-47] mm, P < 0.01), and vertex acuity (70 [61-77] vs. 75 [68-81] degree, P < 0.01). In a multivariable analysis, arch tortuosity remained independently associated with BAV after adjusting for aortic diameter and other clinical characteristics. Conclusions: We found that aortic arch tortuosity is significantly increased in BAV and may identify BAV patients who are at increased risk for TAD. Further studies to evaluate the association between tortuosity and clinical outcomes are in progress. (c) 2018 Elsevier B.V. All rights reserved.
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页码:84 / 89
页数:6
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