Paepalanthus spp: Antimycobacterial activity of extracts, methoxylated flavonoids and naphthopyranone fractions

被引：12

作者：

Moreira, Raquel R. D. ^{[1
]}

Martins, Gilmarcio Z. ^{[1
]}

Pietro, Rosemeire C. L. R. ^{[1
]}

Sato, Daisy N. ^{[1
]}

Pavan, Fernando R. ^{[1
]}

Leite, Sergio R. A. ^{[2
]}

Vilegas, Wagner ^{[2
]}

Leite, Clarice Q. F. ^{[1
]}

机构：

[1] Univ Estado Sao Paulo, Fac Ciencias Farmaceut, BR-14801502 Araraquara, SP, Brazil

[2] Univ Estado Sao Paulo, Inst Quim, BR-14801502 Araraquara, SP, Brazil

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2013年 / 23卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

flavonoids; Mycobacterium; naphthopyranone; Paepalanthus spp; MYCOBACTERIUM-TUBERCULOSIS; ESCHERICHIA-COLI; ANTIBACTERIAL ACTIVITIES; LISTERIA-MONOCYTOGENES; CAMPYLOBACTER-JEJUNI; CONSTITUENTS; ISOCOUMARIN; RESISTANCE; ASSAY;

D O I：

10.1590/S0102-695X2012005000137

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Paepalanthus spp., Eriocaulaceae, are native plants from Brazil known as "sempre-vivas" (everlasting flowers). In this work, we evaluated the potential anti-mycobacterial activity of two methoxylated flavonoids (flavonoid 7-methylquercetagetin and 7-methylquercetagetin-4'-O-beta-D-glucopyranoside) isolated and identified from P. latipes and the naphthopyranone fractions from P. bromeliodes ethanolic extracts. The MIC value of 500 mu g/mL was verified for all compounds tested against M. tuberculosis H37Rv. For M. avium, the MIC value ranged from 1000-2000 mu g/mL excepting to naphthopyranone fractions with MIC of 500 mu g/mL. This is the first report of activity determination of Paepalanthus spp. flavonoids activity against Mycobacterium tuberculosis and M. avium.

引用

页码：268 / 272

页数：5

共 33 条

[1] Antimycobacterial plant terpenoids [J].

Cantrell, CL ;

Franzblau, SG ;

Fischer, NH .

PLANTA MEDICA, 2001, 67 (08) :685-694

[2] The activity of flavones and oleanolic acid from Lippia lacunosa against susceptible and resistant Mycobacterium tuberculosis strains [J].

Castellar, Aline ;

Coelho, Tatiane S. ;

Silva, Pedro E. A. ;

Ramos, Daniela F. ;

Lourenco, Maria Cristina S. ;

Lage, Celso L. S. ;

Juliao, Lisieux S. ;

Barbosa, Ymira G. ;

Leitao, Suzana G. .

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2011, 21 (05) :835-840

[3] Drug-sensitive tuberculosis, multidrug-resistant tuberculosis, and nontuberculous mycobacterial pulmonary disease in nonAIDS adults: comparisons of thin-section CT findings [J].

Chung, Myung Jin ;

Lee, Kyung Soo ;

Koh, Won-Jung ;

Kim, Tae Sung ;

Kang, Eun Young ;

Kim, Sung Mok ;

Kwon, O. Jung ;

Kim, Seonwoo .

EUROPEAN RADIOLOGY, 2006, 16 (09) :1934-1941

[4] A new cytotoxic naphthopyrone dimer from Paepalanthus bromelioides [J].

Coelho, RG ;

Vilegas, W ;

Devienne, KF ;

Raddi, MSG .

FITOTERAPIA, 2000, 71 (05) :497-500

[5] Microplate Alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium [J].

Collins, LA ;

Franzblau, SG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) :1004-1009

[6] Natural product growth inhibitors of Mycobacterium tuberculosis [J].

Copp, Brent R. ;

Pearce, A. Norrie .

NATURAL PRODUCT REPORTS, 2007, 24 (02) :278-297

[7] Pigments of fungi.: Part 70.: Total synthesis of (R)-semixanthomegnin and the X-ray crystal structure of (±)-7-chloro-10-methoxy-3-methyl-3, 4-dihydro-1H-naphtho[2,3-c]pyran-1,6,9-trione [J].

Cotterill, AS ;

Donner, CD ;

Gill, M ;

White, JM .

AUSTRALIAN JOURNAL OF CHEMISTRY, 2003, 56 (01) :49-57

[8] Structure-antimicrobial activity of some natural isocoumarins and their analogues [J].

Devienne, KF ;

Raddi, MSG ;

Coelho, RG ;

Vilegas, W .

PHYTOMEDICINE, 2005, 12 (05) :378-381

[9] Antimicrobial activities of tea catechins and theaflavins and tea extracts against Bacillus cereus [J].

Friedman, M ;

Henika, PR ;

Levin, CE ;

Mandrell, RE ;

Kozukue, N .

JOURNAL OF FOOD PROTECTION, 2006, 69 (02) :354-361

[10] Antibacterial activities of naturally occurring compounds against antibiotic-resistant Bacillus cereus vegetative cells and spores, Escherichia coli, and Staphylococcus aureus [J].

Friedman, M ;

Buick, R ;

Elliott, CT .

JOURNAL OF FOOD PROTECTION, 2004, 67 (08) :1774-1778

← 1 2 3 4 →