New insights into thiol-mediated regulation of adiponectin secretion

被引：16

作者：

Wolf, George ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 USA

来源：

NUTRITION REVIEWS | 2008年 / 66卷 / 11期

关键词：

atherosclerosis; adiponectin; adipose tissue; metabolic syndrome; obesity;

D O I：

10.1111/j.1753-4887.2008.00115.x

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Adiponectin is a protein secreted into the circulation exclusively by adipocytes. It acts as an anti-diabetic and anti-atherogenic adipokine. Its plasma level is lowered in conditions of obesity, diabetes, and atherosclerosis. Within adipocytes, it is retained in the lumen of the endoplasmic reticulum by binding to the thiol protein ERp44 and released by another thiol protein, Ero1-L alpha. Nuclear receptor PPAR gamma ligand agonists appear to regulate its retention-release mechanism. (C) 2008 International Life Sciences Institute

引用

页码：642 / 645

页数：4

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