Fully automated synthesis module for the high yield one-pot preparation of 6-[18F]fluoro-L-DOPA

被引：93
作者：
de Vries, EFJ
Luurtsema, G
Brüssermann, M
Elsinga, PH
Vaalburg, W
机构：
[1] Univ Groningen Hosp, PET Ctr, NL-9700 RB Groningen, Netherlands
[2] Nucl Interface Datentech Strahlungsmessgerate Gmb, D-48145 Munster, Germany
来源：
APPLIED RADIATION AND ISOTOPES | 1999年 / 51卷 / 04期
关键词：
D O I：
10.1016/S0969-8043(99)00057-3
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A fully automated one-pot synthesis of 6-[F-18]fluoro-L-DOPA, an important radiopharmaceutical for studies on the presynaptic dopamine metabolism with positron emission tomography,is described. 6-[F-18]Fluoro-L-DOPA was prepared in high radiochemical yield (33 +/- 4%, c.f.d.) and radiochemical purity (> 99%) in 45 min synthesis time by a fluorodestannylation reaction, followed by acidic removal of the protecting groups. CFCl3 was found to be a better solvent for the fluorodestannylation reaction than CHCl3 or acetonitrile. In CFCl3, [F-18]F-2 was a superior fluorinating agent over [F-18]acetyl hypofluorite. (C) 1999 Elsevier Science Ltd. All rights reserved.
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收藏
页码：389 / 394
页数：6
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