A new spermidine macrocyclic alkaloid isolated from Gymnosporia arenicola leaf

被引：7

作者：

da Silva, Gustavo ^{[1
]}

Martinho, Ana ^{[4
]}

Soengas, Raquel Gonzalez ^{[2
,3
]}

Duarte, Ana Paula ^{[4
]}

Serrano, Rita ^{[1
]}

Gomes, Elsa Teixeira ^{[1
]}

Silva, Olga ^{[1
]}

机构：

[1] Univ Lisbon, Fac Pharm, Res Inst Med iMed ULisboa, P-1649003 Lisbon, Portugal

[2] Univ Aveiro, Dept Chem, P-3810193 Aveiro, Portugal

[3] Univ Aveiro, QOPNA, P-3810193 Aveiro, Portugal

[4] Univ Beira Interior CICS UBI, Hlth Sci Res Ctr, P-6201001 Covilha, Portugal

来源：

FITOTERAPIA | 2015年 / 106卷

基金：

新加坡国家研究基金会;

关键词：

Gymnosporia arenicola; Celastraceae; Macrolactam ring; Spermidine alkaloid; Structural characterization; PLANTS;

D O I：

10.1016/j.fitote.2015.07.020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The isolation and structural elucidation of a macrocyclic alkaloid, characterized by the presence of a 13-membered macrolactam ring containing a spermidine unit N-linked to a benzoyl group is hereby reported. The structure of this previously unknown spermidine alkaloid isolated from Gymnosporia arenicola (Celastraceae) leaves has been elucidated by H-1 and C-13 NMR spectroscopy (including bidimensional analysis) and further characterized by high-resolution mass spectrometry and polarimetry. A route for the biosynthesis of this new bioactive macrocycle is proposed and the cytotoxicity of the compound was evaluated against two ATCC cell lines one normal-derived (MCF10A) and one cancer-derived cell line (MCF7) - using the MTT assay. The alkaloid revealed to be non-cytotoxic against both cell lines. The IC50 values from the cells were also determined. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：7 / 11

页数：5

共 23 条

[1] [Anonymous], ALKALOIDS
[2] [Anonymous], ARKIVOC
[3] [Anonymous], [No title captured]
[4] [Anonymous], 2014, DICT NATURAL PRODUCT
[5] [Anonymous], [No title captured]
[6] Bachrach U., 1973, FUNCTION NATURALLY O
[7] Bachrach U., 1983, Advances in polyamine research, V4
[8] BACLAY AS, 1976, CANCER TREAT REP, V60, P1081
[9] Badawi M M, 1973, Pure Appl Chem, V33, P81, DOI 10.1351/pac197333010081
[10] Polyamine alkaloids
Bienz, S
Bisegger, P
Guggisberg, A
Hesse, M
[J]. NATURAL PRODUCT REPORTS, 2005, 22 (05) : 647 - 658

← 1 2 3 →