Family matters: structural and functional conservation of centromere-associated proteins from yeast to humans

被引：64
作者：
Westermann, Stefan [1 ]
Schleiffer, Alexander [2 ]
机构：
[1] Res Inst Mol Pathol IMP, A-1030 Vienna, Austria
[2] Res Inst Mol Pathol IMP, IMP IMBA Bioinformat Core Facil, A-1030 Vienna, Austria
来源：
TRENDS IN CELL BIOLOGY | 2013年 / 23卷 / 06期
基金：
欧洲研究理事会; 奥地利科学基金会;
关键词：
mitosis; CCAN; kinetochore; nucleosome; histones; CENP-A NUCLEOSOMES; KINETOCHORE-MICROTUBULE ATTACHMENT; DNA-BINDING DOMAIN; BUDDING YEAST; CELL-CYCLE; OUTER KINETOCHORE; CRYSTAL-STRUCTURE; NDC80; COMPLEX; HISTONE-FOLD; AURORA B;
D O I：
10.1016/j.tcb.2013.01.010
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Kinetochores form the fundamental link between chromosomal domains termed centromeres and spindle microtubules in all eukaryotes. This connection, provided by a large, multiprotein complex, is essential for precise chromosome segregation and thus ensures genetic stability. Here, we review recent insights into the composition and function of centromeric chromatin. Multiple approaches have converged to identify centromere-associated proteins from yeast to humans. Among them are newly characterized histone-fold family members that operate at the DNA kinetochore interface and provide critical connections between chromosomes and. microtubules. Together, these findings contribute to a unified view of how centromeric chromatin functions as a regulated scaffold for kinetochore assembly.
引用
收藏
页码：260 / 269
页数：10
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