Regulation of inflammation by adenosine

被引：274

作者：

Hasko, Gyoergy ^{[1
]}

Cronstein, Bruce ^{[2
]}

机构：

[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Surg, Newark, NJ 07103 USA

[2] NYU, Sch Med, Dept Med, New York, NY USA

来源：

FRONTIERS IN IMMUNOLOGY | 2013年 / 4卷

基金：

美国国家卫生研究院;

关键词：

monocytes; macrophages; adenosine; adenosine receptors; neutrophils; NECROSIS-FACTOR-ALPHA; ENDOTHELIAL GROWTH-FACTOR; ALTERNATIVELY ACTIVATED MACROPHAGES; AUGMENTS IL-10 PRODUCTION; SYNERGISTIC UP-REGULATION; A(2A) RECEPTOR AGONISTS; T-CELLS; TNF-ALPHA; IN-VIVO; DIFFERENTIAL REGULATION;

D O I：

10.3389/fimmu.2013.00085

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adenosine, a purine nucleoside generated by the dephosphorylation of adenine nucleotides, is a potent endogenous physiologic and pharmacologic regulator of many functions. Adenosine was first reported to inhibit the inflammatory actions of neutrophils nearly 30 years ago and since then the role of adenosine and its receptors as feedback regulators of inflammation has been well established. Here we review the effects of adenosine, acting at its receptors, on neutrophil and monocyte/macrophage function in inflammation. Moreover, we review the role of adenosine in mediating the anti-inflammatory effects of methotrexate, the anchor drug in the treatment of Rheumatoid Arthritis and other inflammatory disorders.

引用

页数：8

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