Homeostasis of natural killer cells

被引：4
作者：
Rouzaire, Paul
Mayol, Katia
Viel, Sebastien
Bienvenu, Jacques
Walzer, Thierry [1 ]
机构：
[1] Univ Lyon, Lyon, France
来源：
M S-MEDECINE SCIENCES | 2012年 / 28卷 / 04期
关键词：
NK-CELLS; T-CELLS; CYTOMEGALOVIRUS; IL-15; MOUSE; PROLIFERATION; SURVIVAL; MEMORY; RECOGNITION; EXPANSION;
D O I：
10.1051/medsci/2012284018
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Homeostasis of natural killer cells Natural killer (NK) cells are important players of innate immunity, dedicated to the host defense against viruses and also involved in the immune surveillance of tumors. NK cells are widely distributed in the body and their number may increase locally during infection. They develop mainly in the bone marrow and perhaps in other lymphoid organs. They are constantly renewed, with a half-life of about 17 days at the periphery. In this article, we review the factors that regulate the homeostasis of NK cells including their development, differentiation, export to the periphery, their turnover, their homeostatic or antigen-induced proliferation and their survival before or after activation. In addition, we discuss the homeostasis of recently described so-called "memory" NK cells. lozenge
引用
收藏
页码：403 / 408
页数：6
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