Genetic association of the human GAP43 gene with schizophrenia in a Northeast Chinese Han population

被引：1
|
作者：
Luan, Zhilin [1 ]
Ming, Wenhua [1 ]
Huo, Xiaoxiao [1 ]
Yu, Jingwei [2 ]
Wang, Bing [1 ,3 ]
Sun, Yang [4 ]
机构：
[1] Dalian Med Univ, Adv Inst Med Sci, 9 W,S Lvshun Blvd, Dalian 116044, Peoples R China
[2] Guangdong Pharmaceut Univ, Dept Biol, Guangzhou, Peoples R China
[3] Dalian Med Univ, Dalian Municipal Cent Hosp, Dept Endocrinol, Dalian, Peoples R China
[4] Dalian Seventh Peoples Hosp, Dept Psychiat, Dalian, Peoples R China
来源：
INDIAN JOURNAL OF PSYCHIATRY | 2020年 / 62卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Association; GAP; 43; schizophrenia; GAP-43; MESSENGER-RNA; PROTEIN-KINASE; GROWTH; HIPPOCAMPUS; LINKAGE; PHOSPHORYLATION; SYNAPTOPHYSIN; CORTEX; SHESIS; GYRUS;
D O I：
10.4103/psychiatry.IndianJPsychiatry_180_19
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Background: GAP43, a membrane phosphoprotein with high expression level in the developing brains, plays an important role in higher integrative functions of the brain. Materials and Methods: To explore the association of GAP43 with schizophrenia, 11 single-nucleotide polymorphisms (SNPs) were examined in a Northeast Chinese Han sample set consisting of 741 schizophrenia patients and 1330 healthy controls. Results: The results showed that three SNPs were associated with schizophrenia (rs2028248, rs6790048, and rs2164930). Haplotype analysis also revealed a significant association of a strong linkage disequilibrium block (rs2164930-rs119269 76-rs16823991) with schizophrenia. Conclusion: The current findings suggested that the human GAP43 gene may be a susceptibility gene for schizophrenia.
引用
收藏
页码：413 / 417
页数：5
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