Product of natural evolution (SARS, MERS, and SARS-CoV-2); deadly diseases, from SARS to SARS-CoV-2

被引：27
作者：
Shahrajabian, Mohamad Hesam [1 ]
Sun, Wenli [1 ]
Cheng, Qi [1 ,2 ,3 ]
机构：
[1] Chinese Acad Agr Sci, Biotechnol Res Inst, Beijing, Peoples R China
[2] Hebei Agr Univ, Coll Life Sci, Baoding, Hebei, Peoples R China
[3] Global Alliance HeBAU CLS & HeQiS BioAl Mfg, Baoding, Hebei, Peoples R China
来源：
HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2021年 / 17卷 / 01期
关键词：
SARS; coronaviruses; SARS-CoV-2; MERS; pneumonia; emerging diseases; RESPIRATORY SYNDROME-CORONAVIRUS; RECEPTOR-BINDING DOMAIN; DIPEPTIDYL PEPTIDASE 4; ELICITS HIGH TITERS; SPIKE PROTEIN; 2019; COVID-19; IN-VITRO; IMMUNE-RESPONSES; SAUDI-ARABIA; FUNCTIONAL-CHARACTERIZATION;
D O I：
10.1080/21645515.2020.1797369
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
SARS-CoV-2, the virus causing COVID-19, is a single-stranded RNA virus belonging to the order Nidovirales, family Coronaviridae, and subfamily Coronavirinae. SARS-CoV-2 entry to cellsis initiated by the binding of the viral spike protein (S) to its cellular receptor. The roles of S protein in receptor binding and membrane fusion makes it a prominent target for vaccine development. SARS-CoV-2 genome sequence analysis has shown that this virus belongs to the beta-coronavirus genus, which includes Bat SARS-like coronavirus, SARS-CoV and MERS-CoV. A vaccine should induce a balanced immune response to elicit protective immunity. In this review, we compare and contrast these three important CoV diseases and how they inform on vaccine development.
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收藏
页码：62 / 83
页数：22
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