Understanding sex differences in long-term blood pressure regulation: insights from experimental studies and computational modeling

被引:27
作者
Ahmed, Sameed [1 ]
Hu, Rui [1 ]
Leete, Jessica [2 ]
Layton, Anita T. [1 ,3 ,4 ,5 ,6 ]
机构
[1] Univ Waterloo, Dept Appl Math, Waterloo, ON N2L 3G1, Canada
[2] Duke Univ, Computat Biol & Bioinformat Program, Durham, NC USA
[3] Univ Waterloo, Sch Pharm, Waterloo, ON, Canada
[4] Duke Univ, Dept Math, Durham, NC 27706 USA
[5] Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA
[6] Duke Univ, Dept Med, Durham, NC 27706 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2019年 / 316卷 / 05期
关键词
kidney; mathematical modeling; renin-angiotensin system; RENIN-ANGIOTENSIN SYSTEM; SPONTANEOUSLY HYPERTENSIVE-RATS; MATHEMATICAL-MODEL; GENDER-DIFFERENCES; MAINTAINING BALANCE; OXYGEN-CONSUMPTION; RENAL TRANSPORTERS; FEMALE; DIMORPHISM; EXPRESSION;
D O I
10.1152/ajpheart.00035.2019
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Sex differences in blood pressure and the prevalence of hypertension are found in humans and animal models. Moreover, there has been a recent explosion of data concerning sex differences in nitric oxide, the renin-angiotensin-aldosterone system, inflammation, and kidney function. These data have the potential to reveal the mechanisms underlying male-female differences in blood pressure control. To elucidate the interactions among the multitude of physiological processes involved, one may apply computational models. In this review, we describe published computational models that represent key players in blood pressure regulation, and highlight sex-specific models and their findings.
引用
收藏
页码:H1113 / H1123
页数:11
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