Ion-sensitive "isothermal" responsive polymers prepared in water

被引:218
作者
Magnusson, Johannes Pall [1 ]
Khan, Adnan [1 ]
Pasparakis, George [1 ]
Saeed, Aram Omer [1 ]
Wang, Wenxin [1 ]
Alexander, Cameron [1 ]
机构
[1] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England
基金
英国工程与自然科学研究理事会;
关键词
D O I
10.1021/ja802609r
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Ion-sensitive responsive polymers are prepared under fully aqueous conditions using controlled radical polymerization. Variations in comonomer content and sequence lead to temperature and salt-dependent solution behavior, with cloud-points ranging by 40 C following addition of Hofmeister series salts. A "hybrid" block copolymer, composed of a statistical sequence of monomers tipped with a hydrophilic block, formed stable micelle-like assemblies that exhibited burst release of an encapsulated model drug in response to addition of a kosmotrope, Na(2)SO(4), at room temperature.
引用
收藏
页码:10852 / +
页数:3
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