Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections

被引：140
作者：
Magez, S
Radwanska, M
Beschin, A
Sekikawa, K
De Baetselier, P
机构：
[1] Free Univ Brussels VIB, Eenheid CIMM IMOL2, Cellular Immunol Lab, B-1640 Rhode St Genese, Belgium
[2] Free Univ Brussels, Dept Mol Parasitol, Brussels, Belgium
[3] Natl Inst Anim Hlth, Div Host Def Res, Tsukuba, Ibaraki 305, Japan
来源：
INFECTION AND IMMUNITY | 1999年 / 67卷 / 06期
关键词：
D O I：
10.1128/IAI.67.6.3128-3132.1999
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In order to evaluate during experimental Trypanosoma br brucei infections the potential role of tumor necrosis factor alpha (TNF-alpha) in the host-parasite interrelationship, C57BL/6 TNF-alpha knockout mice (TNF-alpha(-/-)) as well as C57BL/6 wild-type mice were infected with pleomorphic T. brucei AnTat 1.1 E parasites, In the TNF-alpha(-/-) mice, the peak levels of parasitemia were strongly increased compared to the peak levels recorded in wild-type mice. The increased parasite burden did not reflect differences in clearance efficacy or in production of T. brucei-specific immunoglobulin M (IgM) and IgG antibodies. Trypanosome-mediated immunopathological features, such as lymph node-associated immunosuppression and lipopolysaccharide hypersensitivity, were found to be greatly reduced in infected TNF-alpha(-/-) mice. These results demonstrate that, during trypanosome infections, TNF-alpha is a key mediator involved in both parasitemia control and infection-associated pathology.
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收藏
页码：3128 / 3132
页数：5
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