Retention of Stereochemistry in Gold-Catalyzed Formal [4+3] Cycloaddition of Epoxides with Arenynamides

被引：62

作者：

Karad, Somnath Narayan ^{[1
]}

Bhunia, Sabyasachi ^{[1
]}

Liu, Rai-Shung ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 35期

关键词：

4+3] cycloaddition; arenynamide; epoxide; gold catalysis; retention; 1,3-DIPOLAR CYCLOADDITION; DERIVATIVES; AZIRIDINES; ACID; ALLENEDIENES; CYCLIZATION; YNAMIDES; ALKENES; ALKYNES; CARBONYLATION;

D O I：

10.1002/anie.201203723

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Golden opportunity: [4+3] Cycloaddition reactions of arenynamides and epoxides are enabled under gold catalysis and have a broad substrate scope (see scheme; Ms=methanesulfonyl). An S N2-type front-side attack of phenyl at the oxiranyl ring is expected to cause the retention of stereochemistry. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8722 / 8726

页数：5

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