Possible Role of the WDR3 Gene on Genome Stability in Thyroid Cancer Patients

被引：6

作者：

Andres Garcia-Quispes, Wilser ^{[1
]}

Pastor, Susana ^{[1
,2
]}

Galofre, Pere ^{[3
]}

Biarnes, Josefina ^{[4
]}

Castell, Joan ^{[3
]}

Velazquez, Antonia ^{[1
,2
]}

Marcos, Ricard ^{[1
,2
]}

机构：

[1] Univ Autonoma Barcelona, Dept Genet & Microbiol, Grp Mutagenesi, Bellaterra, Spain

[2] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ, Madrid, Spain

[3] Hosp Univ Vall dHebron, Nucl Med Serv, Barcelona, Spain

[4] Hosp Josep Trueta, Unitat Endocrinol, Girona, Spain

来源：

PLOS ONE | 2012年 / 7卷 / 09期

关键词：

REPEAT PROTEINS; LYMPHOCYTES; INDIVIDUALS; ASSOCIATION; FREQUENCY; HAPLOTYPE; REGIONS; ASSAY; RISK; SNPS;

D O I：

10.1371/journal.pone.0044288

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The role of the WDR3 gene on genomic instability has been evaluated in a group of 115 differentiated thyroid cancer (DTC) patients. Genomic instability has been measured according to the response of peripheral blood lymphocytes to ionizing radiation (0.5 Gy). The response has been measured with the micronucleus (MN) test evaluating the frequency of binucleated cells with MN (BNMN), both before and after the irradiation. No differences between genotypes, for the BNMN frequencies previous the irradiation, were observed. Nevertheless significant decreases in DNA damage after irradiation were observed in individuals carrying the variant alleles for each of the three genotyped SNPs: rs3754127 [-8.85 (-15.01 to -2.70), P<0.01]; rs3765501 [-8.98 (-15.61 to -2.36), P<0.01]; rs4658973 [-8.70 (-14.94 to -2.46), P<0.01]. These values correspond to those obtained assuming a dominant model. This study shows for the first time that WDR3 can modulate genome stability.

引用

页数：5

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