Targeting autophagy: do patents reveal a therapeutic potential?

被引：2

作者：

Lefranc, Florence ^{[1
,3
]}

Ingrassia, Laurent ^{[4
]}

Kiss, Robert ^{[1
,2
]}

机构：

[1] Free Univ Brussels ULB, Inst Pharm, Toxicol Lab, B-1050 Brussels, Belgium

[2] Fonds Natl Rech Sci, B-1050 Brussels, Belgium

[3] Free Univ Brussels ULB, Erasme Univ Hosp, Dept Neurosurg, Brussels, Belgium

[4] Unibioscreen SA, Brussels, Belgium

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2008年 / 18卷 / 08期

关键词：

apoptosis resistance; autophagy; metastasizing; cancer; neurodegenerative diseases;

D O I：

10.1517/13543776.18.8.813

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Background: Most invasive and/or metastasizing cancers are resistant to apoptosis and, thus, to pro-apoptotic drugs, although certain drugs may display a level of sensitivity to pro-autophagic drugs. Autophagy dysfunction is also associated with neurodegeneration, ageing, and infectious and autoimmune diseases. Objective: To review those patents that have been filed in the specific field of autophagy. Methods: Use was made of two sources to identify pertinent patents: SciFinder Scholar (a division of the American Chemical Society giving access to CAPLUS and MEDLINE databases) and the European Patent Office (giving access to several databases including WIPO and WorldWide databases). Results/conclusions: A total of 18 patents have been published in the field of autophagy, 13 of which have appeared since 2006. Thus, this rising number of patents appears to reinforce the increasing therapeutic potential of targeting autophagy.

引用

页码：813 / 819

页数：7

共 38 条

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