Actin in hair cells and hearing loss

被引：51
作者：
Drummond, Meghan C. [1 ]
Belyantseva, Inna A. [1 ]
Friderici, Karen H. [2 ]
Friedman, Thomas B. [1 ]
机构：
[1] Natl Inst Deafness & Other Commun Disorders, Mol Genet Lab, NIH, Rockville, MD 20850 USA
[2] Michigan State Univ, Dept Microbiol & Mol Genet, Dept Pediat & Human Dev, E Lansing, MI 48824 USA
来源：
HEARING RESEARCH | 2012年 / 288卷 / 1-2期
关键词：
NONSYNDROMIC RECESSIVE DEAFNESS; GENOTYPE-PHENOTYPE CORRELATION; CYTOPLASMIC GAMMA-ACTIN; USHER-SYNDROME PROTEINS; MYOSIN-VIIA GENE; BETA-ACTIN; INNER-EAR; AUTOSOMAL-DOMINANT; UNCONVENTIONAL MYOSIN; TIP-LINK;
D O I：
10.1016/j.heares.2011.12.003
中图分类号：
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号：
100104 ; 100213 ;
摘要：
Hereditary deafness is genetically heterogeneous such that mutations of many different genes can cause hearing loss. This review focuses on the evidence and implications that several of these deafness genes encode actin-interacting proteins or actin itself. There is a growing appreciation of the contribution of the actin interactome in stereocilia development, maintenance, mechanotransduction and malfunction of the auditory system. Published by Elsevier B.V.
引用
收藏
页码：89 / 99
页数：11
相关论文
共 158 条
  • [71] Novel ACTG1 mutation causing autosomal dominant non-syndromic hearing impairment in a Chinese family
    Liu, Ping
    Li, Hu
    Ren, Xiang
    Mao, Haiyan
    Zhu, Qihui
    Zhu, Zhengfeng
    Yang, Rong
    Yuan, Wenlin
    Liu, Jingyu
    Wang, Qing
    Liu, Mugen
    [J]. JOURNAL OF GENETICS AND GENOMICS, 2008, 35 (09) : 553 - 558
  • [72] Mutations in the myosin VIIA gene cause non-syndromic recessive deafness
    Liu, XZ
    Walsh, J
    Mburu, P
    KendrickJones, J
    Cope, MJTV
    Steel, KP
    Brown, SDM
    [J]. NATURE GENETICS, 1997, 16 (02) : 188 - 190
  • [73] β- and γ-actin genes differ in their mechanisms of down-regulation during myogenesis
    Lloyd, C
    Gunning, P
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2002, 84 (02) : 335 - 342
  • [74] TRANSCRIPTIONAL CONTROL OF GENE EXPRESSION BY ACTIN AND MYOSIN
    Louvet, Emilie
    Percipalle, Piergiorgio
    [J]. INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 272, 2009, 272 : 107 - +
  • [75] Identification and molecular modelling of a mutation in the motor head domain of myosin VIIA in a family with autosomal dominant hearing impairment (DFNA11)
    Luijendijk, MWJ
    van Wijk, E
    Bischoff, AMLC
    Krieger, E
    Huygen, PLM
    Pennings, RJE
    Brunner, HG
    Cremers, CWRJ
    Cremers, FPM
    Kremer, H
    [J]. HUMAN GENETICS, 2004, 115 (02) : 149 - 156
  • [76] Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous
    Lynch, ED
    Lee, MK
    Morrow, JE
    Welcsh, PL
    Leon, PE
    King, MC
    [J]. SCIENCE, 1997, 278 (5341) : 1315 - 1318
  • [77] Regulation of Stereocilia Length by Myosin XVa and Whirlin Depends on the Actin-Regulatory Protein Eps8
    Manor, Uri
    Disanza, Andrea
    Grati, M'Hamed
    Andrade, Leonardo
    Lin, Harrison
    Di Fiore, Pier Paolo
    Scita, Giorgio
    Kachar, Bechara
    [J]. CURRENT BIOLOGY, 2011, 21 (02) : 167 - 172
  • [78] Dynamic length regulation of sensory stereocilia
    Manor, Uri
    Kachar, Bechara
    [J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2008, 19 (06) : 502 - 510
  • [79] MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss
    Melchionda, S
    Ahituv, N
    Bisceglia, L
    Sobe, T
    Glaser, F
    Rabionet, R
    Arbones, ML
    Notarangelo, A
    Di Iorio, E
    Carella, M
    Zelante, L
    Estivill, X
    Avraham, KB
    Gasparini, P
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (03) : 635 - 640
  • [80] The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development
    Mogensen, Mette M.
    Rzadzinska, Agnieszka
    Steel, Karen R.
    [J]. CELL MOTILITY AND THE CYTOSKELETON, 2007, 64 (07): : 496 - 508
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