Dietary intake of meat, fruits, vegetables, and selective micronutrients and risk of bladder cancer in the New England region of the United States

被引：44

作者：

Wu, J. W. ^{[1
]}

Cross, A. J. ^{[1
]}

Baris, D. ^{[1
]}

Ward, M. H. ^{[1
]}

Karagas, M. R. ^{[2
]}

Johnson, A. ^{[3
]}

Schwenn, M. ^{[4
]}

Cherala, S. ^{[5
]}

Colt, J. S. ^{[1
]}

Cantor, K. P. ^{[1
,6
]}

Rothman, N. ^{[1
]}

Silverman, D. T. ^{[1
]}

Sinha, R. ^{[1
]}

机构：

[1] NCI, NIH, US Dept HHS, Rockville, MD 20852 USA

[2] Dartmouth Med Sch, Epidemiol & Biostat Sect, Lebanon, NH 03756 USA

[3] Vermont Canc Registry, Burlington, VT 05402 USA

[4] Maine Canc Registry, Augusta, ME 04333 USA

[5] New Hampshire Dept Hlth & Human Serv, Concord, NH 03301 USA

[6] KP Cantor Environm LLC, Silver Spring, MD 20910 USA

来源：

BRITISH JOURNAL OF CANCER | 2012年 / 106卷 / 11期

关键词：

diet; micronutrients; bladder cancer; N-NITROSO COMPOUNDS; FOOD-FREQUENCY QUESTIONNAIRE; PROSPECTIVE COHORT; VITAMIN-C; RED MEAT; HETEROCYCLIC AMINES; UROTHELIAL CANCER; CONSUMPTION; HEALTH; CAROTENOIDS;

D O I：

10.1038/bjc.2012.187

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: Despite many studies on diet and bladder cancer, there are areas that remain unexplored including meat mutagens, specific vegetable groups, and vitamins from diet. METHODS: We conducted a population-based case-control study of bladder cancer in Maine, New Hampshire, and Vermont. A total of 1171 cases were ascertained through hospital pathology records and cancer registries from 2001 to 2004. Overall, 1418 controls were identified from the Department of Motor Vehicles (< 65 years) and Center for Medicaid and Medicare Services (65-79 years) and were frequency-matched to cases by state, sex, and age (within 5 years). Diet was assessed with a self-administered Diet History Questionnaire. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: Processed meat intake was positively associated with bladder cancer (highest vs lowest quartile OR: 1.28; 95% CI: 1.00-1.65; P-trend = 0.035), with a stronger association for processed red meat (OR: 1.41; 95% CI: 1.08-1.84; P-trend = 0.024). There were no associations between intake of fruits or vegetables and bladder cancer. We did, however, observe an inverse association with vitamin B12 intake (OR: 0.77; 95% CI: 0.61-0.99; P = 0.019). CONCLUSION: Vitamin B12 from diet may be protective against bladder cancer, whereas consuming processed meat may increase risk. British Journal of Cancer (2012) 106, 1891-1898. doi:10.1038/bjc.2012.187 www.bjcancer.com Published online 8 May 2012 (C) 2012 Cancer Research UK

引用

页码：1891 / 1898

页数：8

共 59 条

[1] Exposure to heterocyclic aromatic amines from the consumption of cooked red meat and its effect on human cancer risk: A review [J].