Genotoxic Effects of Tributyltin and Triphenyltin Isothiocyanates, Cognate RXR Ligands: Comparison in Human Breast Carcinoma MCF 7 and MDA-MB-231 Cells
被引:17
|
作者:
Hunakova, Luba
论文数: 0引用数: 0
h-index: 0
机构:
Slovak Acad Sci, BMC, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, SlovakiaSlovak Acad Sci, BMC, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, Slovakia
Hunakova, Luba
[1
]
Horvathova, Eva
论文数: 0引用数: 0
h-index: 0
机构:
Slovak Acad Sci, BMC, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, SlovakiaSlovak Acad Sci, BMC, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, Slovakia
Horvathova, Eva
[1
]
Majerova, Karolina
论文数: 0引用数: 0
h-index: 0
机构:
Slovak Acad Sci, BMC, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, SlovakiaSlovak Acad Sci, BMC, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, Slovakia
Majerova, Karolina
[1
]
Bobal, Pavel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet & Pharmaceut Sci Brno, Fac Pharm, Dept Chem Drugs, Palackeho 1946-1, Brno 61242, Czech RepublicSlovak Acad Sci, BMC, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, Slovakia
Bobal, Pavel
[2
]
Otevrel, Jan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet & Pharmaceut Sci Brno, Fac Pharm, Dept Chem Drugs, Palackeho 1946-1, Brno 61242, Czech RepublicSlovak Acad Sci, BMC, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, Slovakia
Otevrel, Jan
[2
]
Brtko, Julius
论文数: 0引用数: 0
h-index: 0
机构:
Slovak Acad Sci, Inst Expt Endocrinol, BMC, Dubravska Cesta 9, Bratislava 84505, SlovakiaSlovak Acad Sci, BMC, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, Slovakia
Brtko, Julius
[3
]
机构:
[1] Slovak Acad Sci, BMC, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, Slovakia
[2] Univ Vet & Pharmaceut Sci Brno, Fac Pharm, Dept Chem Drugs, Palackeho 1946-1, Brno 61242, Czech Republic
[3] Slovak Acad Sci, Inst Expt Endocrinol, BMC, Dubravska Cesta 9, Bratislava 84505, Slovakia
来源:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
|
2019年
/
20卷
/
05期
The cytotoxicity of two recently synthesized triorganotin isothiocyanate derivatives, nuclear retinoid X receptor ligands, was tested and compared in estrogen-receptor-positive MCF 7 and -negative MDA-MB-231 human breast carcinoma cell lines. A 48 h MTT assay indicated that tributyltin isothiocyanate (TBT-ITC) is more cytotoxic than triphenyltin isothiocyanate (TPT-ITC) in MCF 7 cells, and the same trend was observed in the MDA-MB-231 cell line. A comet assay revealed the presence of both crosslinks and increasing DNA damage levels after the 17 h treatment with both derivatives. Differences in cytotoxicity of TBT-ITC and TPT-ITC detected by FDA staining correspond to the MTT data, communicating more pronounced effects in MCF 7 than in the MDA-MB-231 cell line. Both derivatives were found to cause apoptosis, as shown by the mitochondrial membrane potential (MMP) depolarization and caspase-3/7 activation. The onset of caspase activation correlated with MMP dissipation and the total cytotoxicity more than with the amount of active caspases. In conclusion, our data suggest that the DNA damage induced by TBT-ITC and TPT-ITC treatment could underlie their cytotoxicity in the cell lines studied.
机构:
Comenius Univ, Fac Med, Inst Immunol, Odborarske Nam 14, Bratislava 81108, Slovakia
Slovak Acad Sci, Biomed Res Ctr, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, SlovakiaComenius Univ, Fac Med, Inst Immunol, Odborarske Nam 14, Bratislava 81108, Slovakia
Hunakova, Luba
Horvathova, Eva
论文数: 0引用数: 0
h-index: 0
机构:
Slovak Acad Sci, Biomed Res Ctr, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, SlovakiaComenius Univ, Fac Med, Inst Immunol, Odborarske Nam 14, Bratislava 81108, Slovakia
Horvathova, Eva
Matuskova, Miroslava
论文数: 0引用数: 0
h-index: 0
机构:
Slovak Acad Sci, Biomed Res Ctr, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, SlovakiaComenius Univ, Fac Med, Inst Immunol, Odborarske Nam 14, Bratislava 81108, Slovakia
Matuskova, Miroslava
Bobal, Pavel
论文数: 0引用数: 0
h-index: 0
机构:
Masaryk Univ, Fac Pharm, Dept Chem Drugs, Palackeho Trida 1946-1, Brno 61200, Czech RepublicComenius Univ, Fac Med, Inst Immunol, Odborarske Nam 14, Bratislava 81108, Slovakia
Bobal, Pavel
Otevrel, Jan
论文数: 0引用数: 0
h-index: 0
机构:
Masaryk Univ, Fac Pharm, Dept Chem Drugs, Palackeho Trida 1946-1, Brno 61200, Czech RepublicComenius Univ, Fac Med, Inst Immunol, Odborarske Nam 14, Bratislava 81108, Slovakia
Otevrel, Jan
Brtko, Julius
论文数: 0引用数: 0
h-index: 0
机构:
Slovak Acad Sci, Biomed Res Ctr, Inst Expt Endocrinol, Dubravska Cesta 9, Bratislava 84505, SlovakiaComenius Univ, Fac Med, Inst Immunol, Odborarske Nam 14, Bratislava 81108, Slovakia
机构:
Univ Sci Pk Biomed, Slovak Acad Sci, Biomed Res Ctr, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, SlovakiaUniv Sci Pk Biomed, Slovak Acad Sci, Biomed Res Ctr, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, Slovakia
Hunakova, Luba
Horvathova, Eva
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sci Pk Biomed, Slovak Acad Sci, Biomed Res Ctr, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, SlovakiaUniv Sci Pk Biomed, Slovak Acad Sci, Biomed Res Ctr, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, Slovakia
Horvathova, Eva
Gronesova, Paulina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sci Pk Biomed, Slovak Acad Sci, Biomed Res Ctr, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, SlovakiaUniv Sci Pk Biomed, Slovak Acad Sci, Biomed Res Ctr, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, Slovakia
Gronesova, Paulina
Bobal, Pavel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet & Pharmaceut Sci Brno, Dept Chem Drugs, Fac Pharm, Brno, Czech RepublicUniv Sci Pk Biomed, Slovak Acad Sci, Biomed Res Ctr, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, Slovakia
Bobal, Pavel
Otevrel, Jan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vet & Pharmaceut Sci Brno, Dept Chem Drugs, Fac Pharm, Brno, Czech RepublicUniv Sci Pk Biomed, Slovak Acad Sci, Biomed Res Ctr, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, Slovakia
Otevrel, Jan
Brtko, Julius
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sci Pk Biomed, Slovak Acad Sci, Biomed Res Ctr, Inst Expt Endocrinol, Bratislava, SlovakiaUniv Sci Pk Biomed, Slovak Acad Sci, Biomed Res Ctr, Canc Res Inst, Dubravska Cesta 9, Bratislava 84505, Slovakia
机构:
Near East Univ, Dept Med Biol, Fac Med, Nicosia, North Cyprus, TurkeyNear East Univ, Dept Med Biol, Fac Med, Nicosia, North Cyprus, Turkey
Senol, Hulya
Tulay, Pinar
论文数: 0引用数: 0
h-index: 0
机构:
Near East Univ, Dept Med Genet, Fac Med, Nicosia, North Cyprus, Turkey
Near East Univ, Desam Res Inst, Nicosia, CyprusNear East Univ, Dept Med Biol, Fac Med, Nicosia, North Cyprus, Turkey
Tulay, Pinar
Ergoren, Mahmut Cerkez
论文数: 0引用数: 0
h-index: 0
机构:
Near East Univ, Dept Med Genet, Fac Med, Nicosia, North Cyprus, Turkey
Near East Univ, Desam Res Inst, Nicosia, CyprusNear East Univ, Dept Med Biol, Fac Med, Nicosia, North Cyprus, Turkey
Ergoren, Mahmut Cerkez
Hanoglu, Azmi
论文数: 0引用数: 0
h-index: 0
机构:
Near East Univ, Dept Pharmacognosy, Fac Pharm, Nicosia, North Cyprus, TurkeyNear East Univ, Dept Med Biol, Fac Med, Nicosia, North Cyprus, Turkey
Hanoglu, Azmi
Calis, Ihsan
论文数: 0引用数: 0
h-index: 0
机构:
Near East Univ, Dept Pharmacognosy, Fac Pharm, Nicosia, North Cyprus, TurkeyNear East Univ, Dept Med Biol, Fac Med, Nicosia, North Cyprus, Turkey
Calis, Ihsan
Mocan, Gamze
论文数: 0引用数: 0
h-index: 0
机构:
Near East Univ, Dept Med Pathol, Fac Med, Nicosia, North Cyprus, TurkeyNear East Univ, Dept Med Biol, Fac Med, Nicosia, North Cyprus, Turkey
机构:
Shaanxi Normal Univ, Key Lab Minist Educ Med Plant Resources & Nat Pha, Coll Life Sci, Xian 710062, Shaanxi, Peoples R ChinaShaanxi Normal Univ, Key Lab Minist Educ Med Plant Resources & Nat Pha, Coll Life Sci, Xian 710062, Shaanxi, Peoples R China
Li, Long
Chen, Yan
论文数: 0引用数: 0
h-index: 0
机构:
Shaanxi Normal Univ, Key Lab Minist Educ Med Plant Resources & Nat Pha, Coll Life Sci, Xian 710062, Shaanxi, Peoples R ChinaShaanxi Normal Univ, Key Lab Minist Educ Med Plant Resources & Nat Pha, Coll Life Sci, Xian 710062, Shaanxi, Peoples R China
Chen, Yan
Wang, Xiaobing
论文数: 0引用数: 0
h-index: 0
机构:
Shaanxi Normal Univ, Key Lab Minist Educ Med Plant Resources & Nat Pha, Coll Life Sci, Xian 710062, Shaanxi, Peoples R ChinaShaanxi Normal Univ, Key Lab Minist Educ Med Plant Resources & Nat Pha, Coll Life Sci, Xian 710062, Shaanxi, Peoples R China
Wang, Xiaobing
Feng, Xiaolan
论文数: 0引用数: 0
h-index: 0
机构:
Shaanxi Normal Univ, Key Lab Minist Educ Med Plant Resources & Nat Pha, Coll Life Sci, Xian 710062, Shaanxi, Peoples R ChinaShaanxi Normal Univ, Key Lab Minist Educ Med Plant Resources & Nat Pha, Coll Life Sci, Xian 710062, Shaanxi, Peoples R China
Feng, Xiaolan
Wang, Pan
论文数: 0引用数: 0
h-index: 0
机构:
Shaanxi Normal Univ, Key Lab Minist Educ Med Plant Resources & Nat Pha, Coll Life Sci, Xian 710062, Shaanxi, Peoples R ChinaShaanxi Normal Univ, Key Lab Minist Educ Med Plant Resources & Nat Pha, Coll Life Sci, Xian 710062, Shaanxi, Peoples R China
Wang, Pan
Liu, Quanhong
论文数: 0引用数: 0
h-index: 0
机构:
Shaanxi Normal Univ, Key Lab Minist Educ Med Plant Resources & Nat Pha, Coll Life Sci, Xian 710062, Shaanxi, Peoples R ChinaShaanxi Normal Univ, Key Lab Minist Educ Med Plant Resources & Nat Pha, Coll Life Sci, Xian 710062, Shaanxi, Peoples R China
机构:
Hamadan Univ Med Sci, Fac Adv Med Sci & Technol, Dept Tissue Engn & Biomat, Hamadan 6517838736, IranHamadan Univ Med Sci, Fac Adv Med Sci & Technol, Dept Tissue Engn & Biomat, Hamadan 6517838736, Iran
Sabzevari, Alireza Ghannad
Sabahi, Hossein
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran, Fac New Sci & Technol, Dept Life Sci Engn, Tehran 1439957131, IranHamadan Univ Med Sci, Fac Adv Med Sci & Technol, Dept Tissue Engn & Biomat, Hamadan 6517838736, Iran
Sabahi, Hossein
Nikbakht, Mohsen
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran 1411713135, IranHamadan Univ Med Sci, Fac Adv Med Sci & Technol, Dept Tissue Engn & Biomat, Hamadan 6517838736, Iran
Nikbakht, Mohsen
Azizi, Mehdi
论文数: 0引用数: 0
h-index: 0
机构:
Hamadan Univ Med Sci, Fac Adv Med Sci & Technol, Dept Tissue Engn & Biomat, Hamadan 6517838736, IranHamadan Univ Med Sci, Fac Adv Med Sci & Technol, Dept Tissue Engn & Biomat, Hamadan 6517838736, Iran
Azizi, Mehdi
Dianat-Moghadam, Hassan
论文数: 0引用数: 0
h-index: 0
机构:
Isfahan Univ Med Sci, Sch Med, Dept Genet & Mol Biol, Esfahan 8174673461, Iran
Isfahan Univ Med Sci, Pediat Inherited Dis Res Ctr, Esfahan 8174673461, IranHamadan Univ Med Sci, Fac Adv Med Sci & Technol, Dept Tissue Engn & Biomat, Hamadan 6517838736, Iran
Dianat-Moghadam, Hassan
Amoozgar, Zohreh
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Labs Tumor Biol, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02114 USAHamadan Univ Med Sci, Fac Adv Med Sci & Technol, Dept Tissue Engn & Biomat, Hamadan 6517838736, Iran