Sedentary behaviour is associated with elevated C-reactive protein levels in people with psychosis

被引：44
作者：
Stubbs, Brendon [1 ]
Gardner-Sood, Poonam [2 ]
Smith, Shubulade [3 ,4 ]
Ismail, Khalida [3 ,5 ]
Greenwood, Kathryn [6 ,7 ]
Farmer, Ross [1 ]
Gaughran, Fiona [8 ,9 ,10 ]
机构：
[1] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England
[2] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England
[4] South London & Maudsley NHS Fdn Trust, London, England
[5] Kings Coll Hosp London, NHS Fdn Trust, London SE5 8RX, England
[6] Univ Sussex, Sch Psychol, Brighton, E Sussex, England
[7] Sussex Partnership NHS Fdn Trust, Early Intervent Psychosis Serv, Worthing, W Sussex, England
[8] South London & Maudsley NHS Fdn Trust, Natl Psychosis Serv, London, England
[9] Inst Psychiat Psychol & Neurosci, London, England
[10] BRC Nucleus, Biomed Res Ctr, London, England
来源：
SCHIZOPHRENIA RESEARCH | 2015年 / 168卷 / 1-2期
基金：
美国国家卫生研究院;
关键词：
Psychosis; Inflammation; C-reactive protein; Sedentary behaviour; Schizophrenia; Cardiovascular disease; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; SCHIZOPHRENIA; INDIVIDUALS;
D O I：
10.1016/j.schres.2015.07.003
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Psychosis is associated with elevated inflammatory markers including C-reactive protein (CRP), a marker of cardiovascular disease (CVD) risk. Using a cross sectional design, 250 participants with established psychosis (48.2 years (SD 10.2), 39.2% female) were classified as having normal (<5.0 mg/mu l, N = 159) or high CRP levels (>5.0 mg/mu l, N = 91). Regression analysis demonstrated that higher sedentary behaviour was associated with elevated CRP levels (beta = .155, p = .01) after adjustment for confounding variables. Female gender (mu = .229, p = .001), waist circumference (beta = .205, p = .003) and non-white ethnicity (mu = .181, p = .005) were also associated with elevated CRP. Sedentary behaviour is modifiable and increasing physical activity may reduce CRP levels. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：461 / 464
页数：4
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