Sedentary behaviour is associated with elevated C-reactive protein levels in people with psychosis

被引：44
|
作者：
Stubbs, Brendon [1 ]
Gardner-Sood, Poonam [2 ]
Smith, Shubulade [3 ,4 ]
Ismail, Khalida [3 ,5 ]
Greenwood, Kathryn [6 ,7 ]
Farmer, Ross [1 ]
Gaughran, Fiona [8 ,9 ,10 ]
机构：
[1] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England
[2] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England
[4] South London & Maudsley NHS Fdn Trust, London, England
[5] Kings Coll Hosp London, NHS Fdn Trust, London SE5 8RX, England
[6] Univ Sussex, Sch Psychol, Brighton, E Sussex, England
[7] Sussex Partnership NHS Fdn Trust, Early Intervent Psychosis Serv, Worthing, W Sussex, England
[8] South London & Maudsley NHS Fdn Trust, Natl Psychosis Serv, London, England
[9] Inst Psychiat Psychol & Neurosci, London, England
[10] BRC Nucleus, Biomed Res Ctr, London, England
来源：
SCHIZOPHRENIA RESEARCH | 2015年 / 168卷 / 1-2期
基金：
美国国家卫生研究院;
关键词：
Psychosis; Inflammation; C-reactive protein; Sedentary behaviour; Schizophrenia; Cardiovascular disease; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; SCHIZOPHRENIA; INDIVIDUALS;
D O I：
10.1016/j.schres.2015.07.003
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Psychosis is associated with elevated inflammatory markers including C-reactive protein (CRP), a marker of cardiovascular disease (CVD) risk. Using a cross sectional design, 250 participants with established psychosis (48.2 years (SD 10.2), 39.2% female) were classified as having normal (<5.0 mg/mu l, N = 159) or high CRP levels (>5.0 mg/mu l, N = 91). Regression analysis demonstrated that higher sedentary behaviour was associated with elevated CRP levels (beta = .155, p = .01) after adjustment for confounding variables. Female gender (mu = .229, p = .001), waist circumference (beta = .205, p = .003) and non-white ethnicity (mu = .181, p = .005) were also associated with elevated CRP. Sedentary behaviour is modifiable and increasing physical activity may reduce CRP levels. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：461 / 464
页数：4
相关论文
共 50 条
  • [11] Elevated C-reactive protein levels associated with aggressive behavior in Moroccan patients with schizophrenia
    Kachouchi, A.
    Said, D. S.
    Imane, P. A.
    Fatiha, P. M.
    Fatima, P. A.
    EUROPEAN PSYCHIATRY, 2017, 41 : S269 - S269
  • [12] Elevated C-reactive protein levels are associated with endothelial dysfunction in chronic cocaine users
    Meng, QY
    Lima, JA
    Lai, H
    Vlahov, D
    Celentano, DD
    Margolick, JB
    Lai, S
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2003, 88 (2-3) : 191 - 198
  • [13] Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia
    Spracklen, Cassandra N.
    Smith, Caitlin J.
    Saftlas, Audrey F.
    Triche, Elizabeth W.
    Bjonnes, Andrew
    Keating, Brendan J.
    Saxena, Richa
    Breheny, Patrick J.
    Dewan, Andrew T.
    Robinson, Jennifer G.
    Hoh, Josephine
    Ryckman, Kelli K.
    HYPERTENSION IN PREGNANCY, 2017, 36 (01) : 30 - 35
  • [14] CHARACTERISTICS OF WOMEN IN PRETERM LABOR ASSOCIATED WITH ELEVATED C-REACTIVE PROTEIN-LEVELS
    WATTS, DH
    KROHN, MA
    HILLIER, SL
    WENER, MH
    KIVIAT, NB
    ESCHENBACH, DA
    OBSTETRICS AND GYNECOLOGY, 1993, 82 (04): : 509 - 514
  • [15] Elevated C-reactive protein levels are associated with prevalent dementia in the oldest-old
    Kravitz, B. Adar
    Corrada, Maria M.
    Kawas, Claudia H.
    ALZHEIMERS & DEMENTIA, 2009, 5 (04) : 318 - 323
  • [16] Causes and outcomes of markedly elevated C-reactive protein levels
    Landry, Alexander
    Docherty, Peter
    Ouellette, Sylvie
    Cartier, Louis Jacques
    CANADIAN FAMILY PHYSICIAN, 2017, 63 (06) : E316 - E323
  • [17] Elevated C-reactive protein levels in overweight and obese adults
    Visser, M
    Bouter, LM
    McQuillan, GM
    Wener, MH
    Harris, TB
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (22): : 2131 - 2135
  • [18] Elevated levels of C-reactive protein in the serum of asthmatic patients
    Fujita, Miyoshi
    Takeda, M.
    Ito, W.
    Yamaguchi, K.
    Ueki, T. Chiba S.
    Kayaba, H.
    Chihara, J.
    INFLAMMATION RESEARCH, 2007, 56 : S414 - S414
  • [19] C-REACTIVE PROTEIN LEVELS ARE INVERSELY ASSOCIATED WITH NEUROCOGNITIVE PERFORMANCE IN ACUTELY ADMITTED PATIENTS WITH PSYCHOSIS
    Johnsen, Erik
    Fathian, Farivar
    Gjestad, Rolf
    Jorgensen, Hugo A.
    Kroken, Rune A.
    Loberg, Else-Marie
    SCHIZOPHRENIA RESEARCH, 2014, 153 : S122 - S123
  • [20] Abdominal Adiposity Is Associated With Elevated C-Reactive Protein Independent of BMI in Healthy Nonobese People
    Lapice, Emanuela
    Maione, Simona
    Patti, Lidia
    Cipriano, Paola
    Rivellese, Angela A.
    Riccardi, Gabriele
    Vaccaro, Olga
    DIABETES CARE, 2009, 32 (09) : 1734 - 1736
12345