Oocyte vitrification technology has made egg-sharing donation easier in China

被引：30

作者：

Cai, Ling-Bo ^{[1
,2
]}

Qian, Xiao-Qiao ^{[1
,2
]}

Wang, Wei ^{[1
,2
]}

Mao, Yun-Dong ^{[1
,2
]}

Yan, Zheng-Jie ^{[1
,2
]}

Liu, Cui-Zhen ^{[1
,2
]}

Ding, Wei ^{[1
,2
]}

Huang, Jie ^{[1
,2
]}

Chai, De-Chun ^{[1
,2
]}

Chian, Ri-Cheng ^{[1
,2
]}

Liu, Jia-Yin ^{[1
,2
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, State Key Lab Reprod Med, Nanjing 210029, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Affiliated Hosp 1, Ctr Reprod Med, Nanjing 210029, Jiangsu, Peoples R China

来源：

REPRODUCTIVE BIOMEDICINE ONLINE | 2012年 / 24卷 / 02期

关键词：

implantation; live birth; oocyte; pregnancy; sharing donation; vitrification; ONGOING PREGNANCIES; DONOR OOCYTES; FRESH; PROGRAM; ICSI;

D O I：

10.1016/j.rbmo.2011.11.002

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

When infertile women undergoing IVF or intracytoplasmic sperm injection (ICSI) have more than 20 mature oocytes retrieved, at least 15 oocytes are inseminated by their husband's spermatozoa. The extra oocytes are cryopreserved by vitrification. If the patients became pregnant and have healthy live births, the patients are encouraged to donate their remaining cryopreserved oocytes. Forty-seven egg-sharing donors were recruited after having normal deliveries and they donated their remaining oocytes, totalling 395 cryopreserved oocytes, to 75 recipients. The survival rate of vitrified-warmed oocytes was 83.0%. Following insemination by ICSI, the fertilization and cleavage rates were 83.8% and 89.8%, respectively. Out of 75 recipients, 71 recipients completed the treatment cycles and 30 of them became pregnant with clinical pregnancy and implantation rates of 42.3% and 25.5%, respectively. The birthweight of the new-born infants (22 from singleton and two from one set of twins) were 3344.5 +/- 669.1 g and 2425.0 +/- 742.5 g, respectively. No birth defects were observed for the live births. These results indicate that oocyte vitrification is an effective methodology for an egg-sharing donation programme, with acceptable pregnancy and implantation rates. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

引用

页码：186 / 190

页数：5

共 20 条

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