Response of small cell carcinoma of pancreas to a small cell lung cancer regimen: A case report

被引:13
|
作者
Wahid, NA
Neugut, AI
Hibshoosh, H
Brunetti, JC
Fountain, KS
Rubin, M
机构
[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT MED,NEW YORK,NY 10032
[2] COLUMBIA UNIV COLL PHYS & SURG,DEPT PATHOL,NEW YORK,NY 10032
[3] COLUMBIA UNIV COLL PHYS & SURG,DEPT RADIOL,NEW YORK,NY 10032
[4] COLUMBIA UNIV COLL PHYS & SURG,DEPT RADIAT ONCOL,NEW YORK,NY 10032
关键词
D O I
10.3109/07357909609012160
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Small cell carcinoma of the pancreas is a very rare malignancy with 18 cases reported in the literature, of which only 3 were treated with chemotherapy. A 52-year-oId man was diagnosed with small cell carcinoma originating in the head of the pancreas and invading the duodenum. He was treated with a similar approach as for localized small cell lung cancer, with six cycles of combination chemotherapy and local radiotherapy, and went into complete remission. After 3 months, he developed liver metastases along with an enlarged left supraclavicular lymph node. He was treated with two cycles of CVA, but developed lung metastases and was treated with ifosfamide/mesna. However, his overall condition deteriorated and hospice care was instituted until the patient's demise. The patient survived 14 months following diagnosis, significantly longer than the 15 reported patients with small cell pancreatic carcinomas not treated with chemotherapy. Combination chemotherapy and radiation therapy as is utilized for small cell lung cancer appear to be beneficial for small cell carcinoma of the pancreas.
引用
收藏
页码:335 / 339
页数:5
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