Virtual Screening: Is Bigger Always Better? Or Can Small Be Beautiful?

被引：17

作者：

Clark, David E. ^{[1
]}

机构：

[1] Charles River, Harlow CM19 5TR, Essex, England

来源：

JOURNAL OF CHEMICAL INFORMATION AND MODELING | 2020年 / 60卷 / 09期

关键词：

DISCOVERY;

D O I：

10.1021/acs.jcim.0c00101

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This viewpoint is intended to counterbalance some recent publications describing large-scale virtual screening by illustrating how success in launching drug discovery projects has been achieved with much more modest resources. Two examples of small-scale virtual screening that led to the discovery of clinical candidates are cited in favor of this argument.

引用

页码：4120 / 4123

页数：4

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