Tuberculine reaction measured by infrared thermography

Setting: The infection with Mycobacterium tuberculosis gives a delayed immune response, measured by the tuberculine skin test. We present a new technique for evaluation based on automatic detection and measurement of skin temperature due to infrared emission. Design: 34 subjects (46.8+/-16.9 years) (12/22, M/F) with suspected tuberculosis disease were examined with an IR thermal camera, 48h after tuberculin skin injection. Results: In 20 subjects, IR analysis was positive for tuberculine test. Mean temperature of injection area was higher, around 1 degrees C, for the positive group (36.2+/-1.1 degrees C positive group; 35.1+/-1.6 degrees C negative group, p < 0.02 T test for unpaired groups). Conclusion: IR image analysis achieves similar estimation of tuberculin reaction as the visual evaluation, based on higher temperature due to increased heat radiation from the skin lesion. (C) 2015 Elsevier Ireland Ltd. All rights reserved.