Concise total synthesis of (±)-aspidospermidine via an oxidative Hosomi-Sakurai process

被引：70

作者：

Sabot, Cyrille ^{[1
]}

Guerard, Kimiaka C. ^{[1
]}

Canesi, Sylvain ^{[1
]}

机构：

[1] Univ Quebec, Lab Methodol & Synth Prod Nat, Montreal, PQ H3C 3P8, Canada

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 20期

基金：

加拿大自然科学与工程研究理事会;

关键词：

FORMAL 2+3 CYCLOADDITION; HYPERVALENT IODINE(III) REAGENT; BIARYL COUPLING REACTION; ASPIDOSPERMA ALKALOIDS; INDOLE ALKALOIDS; ENANTIOSPECIFIC SYNTHESIS; SUBSTITUTED PHENOLS; TRICYCLIC AMINES; RECENT PROGRESS; DERIVATIVES;

D O I：

10.1039/b903530c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A concise total synthesis of (+/-)-aspidospermidine has been achieved in twelve steps from inexpensive 4-ethylphenol, based on an oxidative Hosomi-Sakurai reaction via the concept of "aromatic ring umpolung".

引用

页码：2941 / 2943

页数：3

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