Concise total synthesis of (±)-aspidospermidine via an oxidative Hosomi-Sakurai process

被引：70
|
作者：
Sabot, Cyrille [1 ]
Guerard, Kimiaka C. [1 ]
Canesi, Sylvain [1 ]
机构：
[1] Univ Quebec, Lab Methodol & Synth Prod Nat, Montreal, PQ H3C 3P8, Canada
来源：
CHEMICAL COMMUNICATIONS | 2009年 / 20期
基金：
加拿大自然科学与工程研究理事会;
关键词：
FORMAL 2+3 CYCLOADDITION; HYPERVALENT IODINE(III) REAGENT; BIARYL COUPLING REACTION; ASPIDOSPERMA ALKALOIDS; INDOLE ALKALOIDS; ENANTIOSPECIFIC SYNTHESIS; SUBSTITUTED PHENOLS; TRICYCLIC AMINES; RECENT PROGRESS; DERIVATIVES;
D O I：
10.1039/b903530c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A concise total synthesis of (+/-)-aspidospermidine has been achieved in twelve steps from inexpensive 4-ethylphenol, based on an oxidative Hosomi-Sakurai reaction via the concept of "aromatic ring umpolung".
引用
收藏
页码：2941 / 2943
页数：3
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