Effects of baicalein isolated from roots of Scutellaria baicalensis Georgi on interleukin 1 beta- and tumour necrosis factor alpha-induced tissue-type plasminogen activator and plasminogen activator inhibitor-1 production in cultured human umbilical vein endothelial cells

被引：0

作者：

Kimura, Y ^{[1
]}

Okuda, H ^{[1
]}

Hayashi, KY ^{[1
]}

Matsushita, N ^{[1
]}

机构：

[1] SUMITOMO MET IND LTD,PHARMACOL LAB,NEW DRUG RES DEPT,HIGH QUAL LIFE RES LABS,BIOMED DIV,KYOTO 61902,JAPAN

来源：

PHYTOTHERAPY RESEARCH | 1997年 / 11卷 / 05期

关键词：

interleukin; 1; beta; tumour necrosis factor-alpha; tissue-type plasminogen activator; plasminogen activator inhibitor-1; human umbilical vein endothelial cells;

D O I：

10.1002/(SICI)1099-1573(199708)11:5<363::AID-PTR106>3.3.CO;2-L

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effects were examined of baicalein on tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) production stimulated by interleukin-1 alpha (IL-1 beta) and tumour necrosis factor-alpha (TNP-alpha) in cultured human vein umbilical endothelial cells (HUVECs), IL-1 beta and TNF-alpha increased PAI-1 production, but they decreased t-PA production, Baicalein isolated from the roots of Scutellaria baicalensis Georgi, inhibited the PAI-1 production stimulated by IL-1 beta and TNF-alpha, but it had no effect on the t-PA, In addition, protein kinase C (PKC) inhibitors such as H7 and sphingosine decreased the reduction of t-PA and the increase of PAI-1 by IL-1 beta and TNF-alpha. On the other hand, dibutryl cAMP and forskolin had no effect on the t-PA reduction and PAI-1 increase by IL-1 beta and TNF-alpha. Moreover, IL-1 beta and TNF-alpha did not cause [Ca2+] elevation. These results suggest that the inhibitory action of baicalein on the PAI-1 production by both cytokines might be directly mediated through PKC inhibition. (C) 1997 by John Wiley & Sons, Ltd.

引用

页码：363 / 367

页数：5