Antioxidant Activity of Herbal Polysaccharides and Cough Reflex

被引：8
作者：
Nosalova, G. [1 ]
Jurecek, L. [1 ]
Hromadkova, Z. [2 ]
Kostalova, Z. [2 ]
Sadlonova, V. [1 ]
机构：
[1] Comenius Univ, Jessenius Fac Med, Dept Pharmacol, Martin 03601, Slovakia
[2] Slovak Acad Sci, Ctr Glyc, Inst Chem, Bratislava, Slovakia
来源：
NEUROBIOLOGY OF RESPIRATION | 2013年 / 788卷
关键词：
Antioxidant activity; Codeine; Cough reflex; Herbal polysaccharides; ANTITUSSIVE ACTIVITY; ARABINOXYLANS; L;
D O I：
10.1007/978-94-007-6627-3_8
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The extraction of Fallopia sachalinensis leaves resulted in two fractions (FS-1 and FS-2). Chemical and spectral analyses of samples revealed the prevalence of pectic polysaccharides with high galacturonic acid, arabinose, galactose, and rhamnose content. Arabinogalactan with a higher content of phenolic prevailed in the FS-1, whereas rhamnogalacturonan predominated in the FS-2 fraction. Both polysaccharides showed significant antioxidant activity according to DPPH and FRAP assays. Evaluation of antitussive activity in healthy adult conscious guinea pigs after oral application of 50 and 75 mg/kg of the FS-2 polysaccharide extracts showed a significant suppression of cough reflex, without an influence on specific airway resistance. The suppression of cough was comparable with that of codeine.
引用
收藏
页码：51 / 57
页数：7
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