Air pollutants have harmful effects on the human health and exacerbate morbidity and mortality. The aim of this study is to assess the short-and long-term effects of the suspended particulate matter with the diameter of smaller than 2.5 mu m (PM2.5), nitrogen dioxide (NO2), and ozone (O-3) on the mortality cases in city of Kerman in 2016 and 2017. In this study, AirQ+ software presented by European Center for Environment and Health and World Health Organization (WHO) was employed. Daily mean concentration of PM2.5, mean hourly concentration of NO2, and maximum 8-h O-3 concentration were used to assess the health impact of human exposure to these pollutants. The mean concentration of PM2.5, NO2, and O-3 in the studied years was higher than the WHO guideline and the mean concentration of NO2 and O-3 was less than the WHO guideline. In the short-term health impact assessment, the death caused by stroke in individuals above 25 years old due to 03 had the highest attributable proportion with 2.48% in 2016 and 2.39% in 2017.Also, in the long-term health impact assessment, the highest attributable proportion for natural death caused by PM2.5 was 15.24% in 2016 and 15.15% in 2017. In general, exposure to air pollutants is a risk factor; therefore, the implementation of sustainable control policies including population growth, urbanization, and traffic control is suggested to avoid the health impacts and economic damages.