The age related association is more pronounced for cystatin C estimated GFR than for creatinine estimated GFR in primary care patients

被引:7
作者
Helmersson-Karlqvist, Johanna [1 ]
Flodin, Mats [1 ]
Hansson, Lars-Olof [1 ]
Larsson, Anders [1 ]
机构
[1] Uppsala Univ, Sect Clin Chem, Dept Med Sci, Uppsala, Sweden
关键词
Age; Creatinine; Cystatin C; Glomerular filtration rate; GLOMERULAR-FILTRATION-RATE; SERUM CREATININE; KIDNEY-FUNCTION; RENAL-DISEASE; CARDIOVASCULAR EVENTS; PREDICTION; EQUATION; DECLINE; VALUES; MARKER;
D O I
10.1016/j.clinbiochem.2013.07.007
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Objectives: There is an age associated change in GFR but this association may be influenced by the method used. The aims of the present study were to assess the association between age and cystatin C and creatinine based glomerular filtration rate estimates in primary care patients, and to determine the proportion of patients with clinically important renal impairment. Materials and methods: 1552 samples with simultaneous requests for creatinine and cystatin C from 1552 primary care patients in the county of Uppsala, Sweden were analysed. MDRD, CKD-EPI and cystatin C equations were used to calculate glomerular filtration rate (GFR) and the associations between GFR and age were explored. Results: The yearly change in cystatin C estimated GFR was 124 mL/min/1.73 m(2) while the corresponding decline for creatinine estimated GFR was 0.76 mL/min/1.73 m(2) for MDRD and 0.99 mL/min/1.73 m(2) for CKD-EPI. Conclusions: The age related association with GFR estimates is smaller for creatinine estimates than for cystatin C estimates. This leads to differences in the number of patients with reduced eGFR detected with the three estimates and the patient treatment will depend on the estimate used. This is not coherent with a good patient care and we thus need to develop new eGFR equations with better agreement between the estimates. (C) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:1761 / 1763
页数:3
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