Cutaneous Angiosarcoma: A Single-Institution Experience

被引:58
作者
Perez, Matthew C. [1 ]
Padhya, Tapan A. [2 ]
Messina, Jane L. [3 ,4 ]
Jackson, Ryan S. [1 ,2 ]
Gonzalez, Ricardo J. [4 ,5 ]
Bui, Marilyn M. [3 ,5 ]
Letson, G. Douglas [5 ]
Cruse, C. W. [4 ]
Lavey, Robert S. [6 ]
Cheong, David [5 ]
Forster, Meghan R. [4 ]
Fulp, William J. [7 ]
Sondak, Vernon K. [4 ,5 ]
Zager, Jonathan S. [4 ,5 ]
机构
[1] Univ S Florida, Morsani Coll Med, Tampa, FL 33620 USA
[2] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Head & Neck Oncol, Tampa, FL 33682 USA
[3] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Pathol, Tampa, FL 33682 USA
[4] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Cutaneous Oncol, Tampa, FL 33682 USA
[5] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Sarcoma Oncol, Tampa, FL 33682 USA
[6] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Radiat Oncol, Tampa, FL 33682 USA
[7] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Biostat, Tampa, FL 33682 USA
关键词
ATYPICAL VASCULAR-LESIONS; SOFT-TISSUE; RADIATION; SCALP; MANAGEMENT; SARCOMAS; OUTCOMES; SURGERY; THERAPY; BREAST;
D O I
10.1245/s10434-013-3083-6
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cutaneous angiosarcoma (CAS) is a rare, aggressive vascular sarcoma with a poor prognosis, historically associated with 5-year overall survival (OS) rates between 10 and 30 %. This is a single-institution retrospective review of patients treated for CAS from 1999-2011. Demographics, primary tumor characteristics, treatment, and outcomes were analyzed. A total of 88 patients were identified (median age 70 years and 57 % female). Median tumor size was 3 cm. Median follow-up was 22 months. The 5-year OS and recurrence-free survival (RFS) were 35.2 and 32.3 %, respectively; median was 22.1 months. Also, 36 patients (41 %) received surgery alone, 7 (8 %) received XRT alone, and 41 (47 %) received surgery and XRT. Of the 67 of 88 patients who were disease-free after treatment, 33 (50 %) recurred (median of 12.3 months). Surgery alone had the highest 5-year OS (46.9 %) and RFS (39.9 %) (p = ns). Four presentation groups were identified: (1) XRT-induced, n = 30 (34 %), 26 of 30 occurred in females with a prior breast cancer, (2) sporadic CAS on head and neck (H/N), n = 38, (3) sporadic CAS on trunk/extremities, n = 13, and (4) Stewart-Treves n = 7. Those with trunk/extremity CAS had the highest 5-year OS (64.8 %), with H/N CAS having the worst 5-year OS (21.5 %). On MV analysis, only tumor size < 5 cm correlated with improved OS (p = 0.014). In this large series, there appears to be a better overall prognosis than historically reported, especially in Stewart-Treves and CAS on trunk or extremities. While surgery alone was associated with better OS and RFS compared with other treatment modalities, this was not statistically significant. Tumor size was a significant prognostic factor for OS.
引用
收藏
页码:3391 / 3397
页数:7
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