Gold and Palladium Combined for the Sonogashira Coupling of Aryl and Heteroaryl Halides

被引：32
作者：
Panda, Biswajit [1 ]
Sarkar, Tarun K. [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India
来源：
SYNTHESIS-STUTTGART | 2013年 / 45卷 / 06期
关键词：
gold catalysis; cross-coupling; Sonogashira coupling; gold-palladium combined; COPPER-FREE; TERMINAL ALKYNES; EFFICIENT; CATALYSIS; ENYNES; ACETYLENES; BROMIDES; WATER;
D O I：
10.1055/s-0032-1318119
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient gold and palladium combined methodology for the Sonogashira coupling of a wide array of electronically and structurally diverse aryl and heteroaryl halides is described. The orthogonal reactivity of the two metals shows high selectivity and extreme functional group tolerance in Sonogashira coupling. A brief mechanistic study reveals that the gold acetylide intermediate enters into the palladium catalytic cycle at the transmetalation step.
引用
收藏
页码：817 / 829
页数：13
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