Autoimmune Rheumatic Diseases 2 Systemic lupus erythematosus and other autoimmune rheumatic diseases: challenges to treatment

被引：96

作者：

Murphy, Grainne ^{[1
]}

Lisnevskaia, Larissa ^{[2
]}

Isenberg, David ^{[1
]}

机构：

[1] Univ Coll London Hosp, Ctr Rheumatol, Dept Med, London WC1E 6JF, England

[2] Oshawa Clin, Oshawa, ON, Canada

来源：

LANCET | 2013年 / 382卷 / 9894期

关键词：

STEM-CELL TRANSPLANTATION; NECROSIS-FACTOR-ALPHA; COMPLEMENTARITY-DETERMINING REGION-1; PROTEASOME INHIBITOR BORTEZOMIB; PRIMARY SJOGRENS-SYNDROME; PLACEBO-CONTROLLED TRIAL; TERM-FOLLOW-UP; DOUBLE-BLIND; MONOCLONAL-ANTIBODY; MYCOPHENOLATE-MOFETIL;

D O I：

10.1016/S0140-6736(13)60889-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Increased understanding of the molecular mechanisms underlying the pathogenenesis of autoimmune rheumatic diseases has led to targeted biological treatments that modulate various aspects of the immune response. These new treatments, together with more judicious use of other immunosuppressive drugs, have resulted in marked improvements in morbidity and mortality. Although belimumab, an agent that inhibits B-cell survival, is the first drug to be approved by the US Food and Drug Administration for the treatment of systemic lupus erythematosus in 50 years, many other immunological targets are under investigation. We discuss the recent advances in the biological treatment of autoimmune rheumatic diseases, with a particular focus on systemic lupus erythematosus.

引用

页码：809 / 818

页数：10

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