Receiver Operating Characteristic Analysis of Diffusion-Weighted Magnetic Resonance Imaging in Differentiating Hepatic Hemangioma From Other Hypervascular Liver Lesions

Purpose: To evaluate the role of diffusion-weighted imaging in differentiating between hepatic hemangiomas, both typical and atypical, and other hypervascular liver lesions. Methods: Retrospective review of 182 hypervascular liver lesions in 117 patients was performed. Diffusion and contrast-enhanced magnetic resonance imaging were performed using a 1.5-T unit. Imaging protocol consisted of T-2-weighted fast spin-echo images, breath-hold diffusion-weighted echo-planar images, and breath-hold unenhanced and contrast-enhanced T-1-weighted 3-dimensional fat-suppressed spoiled gradient-echo images in the arterial phase (20 seconds) and portal venous phase (60 seconds). Signal intensity changes and apparent diffusion coefficient (ADC) values were evaluated for all lesions. Unpaired t test was used to compare the mean ADC values for different lesions, and statistical significance was set at P < 0.01. Receiver operating characteristic analysis was used to determine the accuracy of diffusion-weighted imaging in differentiating hemangiomas from other hypervascular liver lesions. Results: Lesions included typical and atypical hemangioma (n = 38), hepatocellular carcinoma (HCC, n = 58), focal nodular hyperplasia (FNH; n = 22), and neuroendocrine tumor metastasis (NETS n = 64) with a mean tumor size of 5.3 cm. Mean ADC value for hemangioma, HCC, FNH, and NET was 2.29 x 10(-3), 1.55 x 10(-3) 1.65 x 10(-3) and 1.43 x 10(-3) mm(2)/s, respectively. There was a statistically significant difference in the ADC Value of hemangioma compared with that of FNH (P < 0.001) HCC (P < 0.001), and NET (P < 0.001), respectively. The area under the receiver operating characteristic curve was 0.91. Conclusions: Diffusion-weighted magnetic resonance imaging and ADC maps call provide rapid quantifiable information to differentiate typical and atypical hemangiomas from other hypervascular liver lesions.