Cytokine nephropathy in a patient with fatal Epstein-Barr virus-associated hemophagocytic syndrome

被引：5

作者：

Nagayama, Yoshikuni ^{[1
]}

Yoshimura, Ashio ^{[1
]}

Iwasaki, Shigeki ^{[2
]}

机构：

[1] Showa Univ, Dept Med, Div Nephrol, Fujigaoka Hosp, Yokohama, Kanagawa 2278501, Japan

[2] Seirei Yokohama Hosp, Dept Nephrol & Hypertens, Yokohama, Kanagawa, Japan

来源：

RENAL FAILURE | 2013年 / 35卷 / 10期

关键词：

Acute kidney injury (AKI); cytokine; cytokine nephropathy; Epstein-Barr virus (EBV); hemophagocytic syndrome (HPS); ACUTE-RENAL-FAILURE; INFECTIOUS-MONONUCLEOSIS; LYMPHOHISTIOCYTOSIS; DYSFUNCTION; DISORDERS; DIAGNOSIS;

D O I：

10.3109/0886022X.2013.828358

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Occasionally, patients with acute Epstein-Barr virus (EBV) infection develop hemophagocytic syndrome (HPS). Acute kidney injury (AKI) is considered a strong prognostic factor, but very few data are available about the biopsy-proven renal involvement of EBV-HPS. Here we describe a previously healthy 17-year-old girl with EBV-HPS. Combination therapy failed and renal necropsy was performed. The renal histology showed that intact glomeruli, remarkable interstitial edema and some cellular infiltration, and protein casts. These findings were compatible with cytokine nephropathy as recently advocated. We suggest that hypercytokinemia may play an important role in the pathophysiology in AKI of EBV-HPS.

引用

页码：1445 / 1448

页数：4

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