Polymorphism of CAG Repeats in Exon 1 of the Androgen Receptor Gene in Russian Men with Various Forms of Pathozoospermia

被引：2

作者：

Melikyan, L. P. ^{[1
]}

Bliznetz, E. A. ^{[1
]}

Polyakov, A. V. ^{[1
]}

Mironovich, O. L. ^{[1
]}

Kuznetsova, I. A. ^{[1
]}

Sorokina, T. M. ^{[1
]}

Shtaut, M. I. ^{[1
]}

Sedova, A. O. ^{[1
]}

Kurilo, L. F. ^{[1
]}

Solovova, O. A. ^{[1
]}

Chernykh, V. B. ^{[1
]}

机构：

[1] Res Ctr Med Genet, Moscow 115522, Russia

来源：

RUSSIAN JOURNAL OF GENETICS | 2020年 / 56卷 / 08期

关键词：

androgen receptor; male infertility; spermatogenesis; pathozoospermia; trinucleotide repeats; MALE-INFERTILITY; EXPANSION; SPERMATOGENESIS; ASSOCIATION; LENGTH; SIZE;

D O I：

10.1134/S1022795420080104

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

CAG(n)polymorphism in exon 1 of the androgen receptor (AR/HUMARA) gene is associated with pathozoospermia and male infertility, but its effect on spermatogenesis and male fertility is not well understood. The article presents the results of a study of CAG repeats polymorphism of theARgene in Russian patients with pathozoospermia (n= 591), fertile men (n= 286), and normozoospermic men/control (n= 131). Comparative analysis showed no significant differences in frequencies of "medium" (n= 19-25), "long" (n >= 26), and "short" (n <= 18) alleles between groups of patients with various forms of pathozoospermia. Statistically significant (p< 0.01) differences were found between the group with severe oligozoospermia and the control for the prevalence of "long" and "short" CAG alleles, as well as for the frequency of CAG(n)= 25 allele between azoospermic (18.1%) and severe oligozoospermic (2.6%) men.

引用

页码：1000 / 1005

页数：6

共 25 条

[1]

[Anonymous], 2012, WHO GUIDELINES STUDY

[2] Molecular analysis of CAG repeat length of the androgen receptor gene and Y chromosome microdeletions among Jordanian azoospermic infertile males [J].