Finding better therapeutic targets for patients with asthma: adenosine receptors?

被引：4

作者：

Polosa, R. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Catania, Dipartimento Med Interna & Specialist, Inst Internal Med & Clin Immunol, S Marta Hosp, I-95124 Catania, Italy

[2] CV Therapeut, Palo Alto, CA USA

[3] Duska Therapeut, La Jolla, CA 92037 USA

[4] NeuroSearch, Ventura, CA 93003 USA

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2008年 / 155卷 / 04期

关键词：

adenosine; adenosine receptors; inflammation; asthma; airways; adenosine receptor agonists; adenosine receptor antagonists;

D O I：

10.1038/bjp.2008.364

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent observations suggest a potential pathophysiological function for adenosine signalling in chronic inflammation of the airways, and development of new selective agonists or antagonists for adenosine receptor subtypes has recently lead to a number of clinical trials of such agents in asthma. The review by Wilson in this issue of the BJP provides a critical perspective on adenosine receptors as rational targets for drug development for anti-asthma drugs with a focus on their efficacy and safety. Important conclusions can be drawn about the function of adenosine receptors in human asthma and approaches to these important targets with novel therapeutic agents.

引用

页码：441 / 443

页数：3

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